β-CD-C14TAB complex-coated 5CB droplets are designed by the adsorption of β-CD-C14TAB complexes at the 5CB/aqueous interface. We show that the 5CB droplets can be used as an optical probe for the selective detection of cholic acid in aqueous solution containing uric acid and urea via competitive host-guest recognition.
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Article Synopsis
- Various harmful substances can negatively impact the liver, leading to conditions like hepatocellular carcinoma (HCC), drug-induced liver injury (DILI), and non-alcoholic fatty liver disease (NAFLD), making accurate detection and monitoring essential for effective treatment.
- Carboxylesterase 2 (CES2) is a liver enzyme that can serve as a potential biomarker for these diseases, and the development of a new fluorescent probe (LAN-CA) using cholic acid improves detection accuracy.
- The LAN-CA probe shows enhanced specificity and sensitivity in detecting CES2 in live cells and performs well in imaging liver disease models, indicating its potential for better diagnosis and monitoring of liver conditions.
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