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Conservative management of cervical intraepithelial neoplasia 2 and prediction of its progression - a retrospective study.
Rom J Morphol Embryol
November 2024
Discipline of Ophthalmology, Department of Surgery II, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania; Department of Ophthalmology, Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania; Department of Obstetrics and Gynecology, Faculty of Medicine, Doctoral School, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania;
Aim: Cervical intraepithelial neoplasia 2 (CIN2) evolution is controversial, and some of them regress spontaneously in a two-year follow-up. The purpose of this work was to evaluate the percentage of CIN2 progression or persistence during a 24-month follow-up, using clinical predictors such as human papillomavirus (HPV) genotype and cytology results.
Patients, Materials And Methods: This is a retrospective case-control study and included patients of reproductive age who had a new diagnosis of CIN2 who were monitored for lesion regression (Group 1, n=72 patients), and progression or persistence (Group 2, n=36 patients).
Viral whole genome sequencing reveals high variations in APOBEC3 editing between HPV risk categories.
J Med Virol
October 2024
Université Paris Cité, Inserm IAME UMR 1137, Paris, F-75018, France.
Article Synopsis
- * A study involving 30 Togolese female sex workers analyzed 156 HPV genome sequences from cervical and anal swabs, revealing identical infections but varying genetic diversity across HPV types and sites.
- * Low-risk HPVs showed more mutations induced by APOBEC3 in the E4 and E6 genes compared to high-risk HPVs, which had fewer mutations, suggesting different cancer risk potentials among HPV types.
Clinical and ultrasound features of uterine perivascular epithelioid cell tumors: case series and literature review.
Ultrasound Obstet Gynecol
November 2024
Department of Ultrasonic Medicine, West China Second Hospital of Sichuan University, Chengdu, Sichuan, China.
Article Synopsis
- The study aimed to characterize the clinical and ultrasound features of uterine perivascular epithelioid cell tumors (PEComa) using standardized medical terminology.
- A total of five patients, aged 33 to 57, diagnosed with PEComa were analyzed, revealing both benign and malignant cases with common symptoms like vaginal discharge and abdominal pain.
- Although ultrasound often misidentified these tumors (some as fibroids or cervical cancer), it showed many lesions as round, highlighting the need for accurate diagnosis and effective treatment strategies, including surgery and chemotherapy for malignant cases.
Review of triage strategies for atypical squamous cells of undetermined significance among young women.
Int J Gynaecol Obstet
February 2025
Department of Gynecology-Obstetrics, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.
In the present study we reviewed the existing literature regarding management approaches for ASC-US and highlight their pros and cons. The ASC-US entity emerged from Bethesda classification 2001. We conducted this review using search words ASC-US triage, ASC-US management in young women, triage tests for ASC-US, and ASC-US outcome from the English literature.
View Article and Find Full Text PDF[Clinical characteristics analysis of heterotopic cervical pregnancy].
Zhonghua Yi Xue Za Zhi
September 2024
National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Ministry of Education Key Laboratory of Assisted Reproduction (Peking University), Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
To investigate the clinical characteristics of heterotopic cervical pregnancy (HCP). A retrospective analysis was conducted based on the general clinical data, assisted reproductive technology (ART) data, diagnosis and treatment data, and pregnancy outcomes of 17 patients diagnosed with HCP who received ART at the Reproductive Medicine Center of Peking University Third Hospital from January 2011 to April 2022. The age of 17 HCP patients was (34.
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