Glucose is the fundamental energy source for life; thus cells need to respond appropriately to changes in available glucose concentration. We investigated the relationship between media glucose concentration and respiration-dependency of proliferation, using Schizosaccharomyces pombe. In media containing ≥ 0.2% glucose, neither antimycin A, an inhibitor of Complex III, nor gene deletions of essential electron transfer chain components, impaired cell division, while these factors completely inhibited cell division in media containing ≤ 0.1% glucose. These results indicate the existence of a threshold in glucose concentration that governs respiration-dependency of S. pombe proliferation.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mito.2015.04.003DOI Listing

Publication Analysis

Top Keywords

glucose concentration
16
schizosaccharomyces pombe
8
cell division
8
glucose
6
critical glucose
4
concentration
4
concentration respiration-independent
4
respiration-independent proliferation
4
proliferation fission
4
fission yeast
4

Similar Publications

Background: An association exists between obesity and reduced testosterone levels in males. The propose of this research is to reveal the correlation between 15 indices linked to obesity and lipid levels with the concentration of serum testosterone, and incidence of testosterone deficiency (TD) among adult American men.

Methods: The study utilized information gathered from the National Health and Nutrition Examination Survey (NHANES) carried out from 2011 to 2016.

View Article and Find Full Text PDF

Clinical and biochemical factors associated with amygdalar metabolic activity.

NPJ Aging

January 2025

Division of Cardiovascular Medicine, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Japan.

We investigated clinical factors and biochemical markers associated with amygdalar metabolic activity evaluated by [F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) in 346 subjects without a history of malignant neoplasms. Univariate regression analysis revealed significant relationships between amygdalar metabolic activity and fasting plasma glucose (FPG), glycated hemoglobin, coronary artery disease (CAD) history, aspirin use, oral hypoglycemic agents (OHAs) use, and asymmetric dimethylarginine (ADMA). In multiple stepwise regression analysis, FPG and CAD history were independently associated with amygdalar metabolic activity.

View Article and Find Full Text PDF

Objectives: Critically ill newborn infants often require simultaneous administration of multiple intravenous (IV) solutions through the same catheter lumen, making compatibility of these solutions crucial in neonatal intensive care units (NICUs). This study aimed to investigate the physical compatibility of insulin aspart, lidocaine, alprostadil and vancomycin with individualised two-in-one parenteral nutrition (PN).

Methods: The study was conducted at the hospital pharmacy's drug compounding facility of the University Medical Centre Utrecht.

View Article and Find Full Text PDF

Electrochemical pH modulator coupled with Ni-based electrode for glucose sensing.

Talanta

January 2025

Université de Lorraine, CNRS, Laboratoire de Chimie Physique et Microbiologie pour Les Matériaux et L'Environnement (LCPME), Nancy F-54000, France.

The non-enzymatic electrochemical detection of glucose by direct oxidation using electrodes modified with suitable electrocatalysts is now well-established. However, it most often requires highly alkaline media, limiting dramatically the use of such electrodes at neutral pH. This is notably the case of Ni-based electrodes.

View Article and Find Full Text PDF

This study assessed the reliability of Roche Accu-Chek Inform II glucometers in a real-world setting. A retrospective analysis was conducted on 6,695 paired results. Capillary samples were tested using Roche Accu-Chek Inform II glucometers, while venous samples were analyzed using Roche Cobas c503/702 analyzers.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!