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Rectal Hodgkin lymphoma in a patient with ulcerative colitis: a case study. | LitMetric

Rectal Hodgkin lymphoma in a patient with ulcerative colitis: a case study.

Diagn Pathol

Institute of Pathology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.

Published: April 2015

AI Article Synopsis

  • * Despite initial biopsies showing no cancer, surgery was performed to diagnose and treat the stenosis, ultimately revealing nodular sclerosis classical Hodgkin lymphoma, linked to Epstein-Barr Virus.
  • * The patient is now undergoing chemotherapy for the disseminated disease, which has shown signs of remission; this case highlights the increased risk of lymphoproliferative disorders in patients under immunosuppressive therapy.

Article Abstract

A case of Hodgkin lymphoma located in the rectum of a patient with ulcerative colitis is described. The patient was a 44 year old male treated with thiopurines for ulcerative colitis for ten years. He was admitted with malaise, weight loss and abdominal pain. Endoscopy revealed a large ulcerative lesion involving the rectum and distal part of the sigmoid colon. Although it macroscopically resembled a rectal cancer, repeated biopsies did not reveal any malignancy. In order to resolve the symptoms of stenosis and to get the final diagnosis a recto-sigmoid resection was performed. Pathologic examination revealed nodular sclerosis classical Hodgkin lymphoma, positive for Epstein Barr Virus. Subsequent examination revealed disseminated disease involving the pelvic wall, liver, and bone marrow. The patient is currently receiving chemotherapeutic treatment, and follow-up shows disease remission.Hodgkin lymphoma associated with immunosuppressive therapy is rare. However, patients with ulcerative colitis receiving such treatment are at increased risk of lymphoproliferative disordes, potentially due to loss of immunosurveillance and presence of oncogenic viruses (i.e. Epstein-Barr virus). Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6156776351558952.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427961PMC
http://dx.doi.org/10.1186/s13000-015-0271-7DOI Listing

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