AI Article Synopsis
- Post-transcriptional regulation is crucial for gene expression and affects processes like metabolism, embryogenesis, and immune responses.
- Hepatitis C virus (HCV) manipulates the host's post-transcriptional regulatory systems to evade immune responses while also facing counteractions from host components trying to limit viral replication.
- The review examines the complex interactions between post-transcriptional mechanisms in HCV infection, showcasing the ongoing struggle between the virus and the host for control.
Article Abstract
Post-transcriptional regulation of gene expression plays a pivotal role in various gene regulatory networks including, but not limited to metabolism, embryogenesis and immune responses. Different mechanisms of post-transcriptional regulation, which can act individually, synergistically, or even in an antagonistic manner have been described. Hepatitis C virus (HCV) is notorious for subverting host immune responses and indeed exploits several components of the host's post-transcriptional regulatory machinery for its own benefit. At the same time, HCV replication is post-transcriptionally targeted by host cell components to blunt viral propagation. This review discusses the interplay of post-transcriptional mechanisms that affect host immune responses in the setting of HCV infection and highlights the sophisticated mechanisms both host and virus have evolved in the race for superiority.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472456 | PMC |
| http://dx.doi.org/10.1016/j.coviro.2015.02.006 | DOI Listing |
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