Induction and recovery characteristics of propofol, thiopental and etomidate.

Acta Anaesthesiol Scand

Department of Anesthesia, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark.

Published: November 1989

Propofol, thiopental and etomidate, with 20 patients in each group, were compared for anesthesia of short duration in women undergoing termination of pregnancy, with respect to: 1: pain on injection (equally often after propofol and etomidate, but more rarely after thiopental); 2: apnea following induction (no difference); 3: involuntary muscular movements more frequent after etomidate); 4: blood pressure (larger drop after propofol); 5: heart rate (greater increase after thiopental); 6: time to eye opening on command (longer after propofol); 7: Steward score on eye opening (no difference); 8: coin counting after 15, 30 and 60 min (performance better after propofol at 15 and 30 min, producing even shorter times than preoperatively at 60 min); 9: reaction time after 15, 30 and 60 min (performance better after propofol, producing even shorter times than preoperatively at 60 min. It is concluded that the faster recovery gives propofol an advantage over thiopental and etomidate in outpatient anesthesia.

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1399-6576.1989.tb02993.xDOI Listing

Publication Analysis

Top Keywords

thiopental etomidate
12
propofol
8
propofol thiopental
8
eye opening
8
min performance
8
performance better
8
better propofol
8
producing shorter
8
shorter times
8
times preoperatively
8

Similar Publications

The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review.

CNS Drugs

January 2025

Department of Anesthesiology, Jefferson Surgical Center Endoscopy, Sidney Kimmel Medical College, Jefferson Health, 111 S 11th Street, #7132, Philadelphia, PA, 19107, USA.

GABA (γ-aminobutyric acid) receptors are constituents of many inhibitory synapses within the central nervous system. They are formed by 5 subunits out of 19 various subunits: α1-6, β1-3, γ1-3, δ, ε, θ, π, and ρ1-3. Two main subtypes of GABA receptors have been identified, namely GABAA and GABAB.

View Article and Find Full Text PDF
Article Synopsis
  • Laryngoscopy and tracheal intubation can increase sympathetic responses, potentially harmful in patients with heart issues; this study compares etomidate to a midazolam-sodium thiopental combination for their effects on these responses.
  • Conducted as a double-blind, randomized trial with 39 patients in each group, results indicated no significant differences in demographic factors, but the etomidate group had a shorter laryngoscopy time.
  • While mean diastolic and arterial pressures were lower in the midazolam-thiopental group at 10 minutes post-intubation, overall, both medications similarly managed cardiovascular responses with no significant adverse reactions noted.
View Article and Find Full Text PDF

Around anesthesia: anesthetic aspects of electroconvulsive treatment in the light of the latest reports - review article.

Psychiatr Pol

February 2024

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach Katedra i Klinika Psychiatrii Dorosłych.

Electroconvulsive therapy (ECT) remains the most effective method of treating acute mental conditions in psychiatry. The progress that has been made in anesthesiology in recent years allows for the personalization and optimization of electroconvulsive therapy through purely anesthetic interventions. There are few procedures in medicine where anesthesia would have such a direct impact on the effectiveness, or even success, of a given procedure.

View Article and Find Full Text PDF

Intravenous (IV) medication administration error remains a major concern during the perioperative period. This review examines inadvertent IV anaesthesia induction agent administration via high-risk routes. Using Medline and Google Scholar, the author searched published reports of inadvertent administration via neuraxial (intrathecal, epidural), peripheral nerve or plexus or intracerebroventricular (ICV) route.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!