AI Article Synopsis
- BK polyomavirus commonly infects people, but serious symptoms primarily occur in those with weakened immune systems, like transplant patients.
- A 15-year-old girl with leukemia had a hematopoietic stem cell transplant and experienced a reactivation of the virus leading to severe urinary and kidney issues.
- This case highlights an unusual immune response (polyclonal gammopathy) linked to kidney damage caused by the BK virus, confirmed through detailed medical tests.
Article Abstract
Background: BK polyomavirus infects most of the general population. However, its clinical manifestations are almost exclusively seen in immunocompromised patients, particularly in kidney and hematopoietic stem cell transplantation recipients.
Case Presentation: A 15-y-old female suffering from common B-cell acute lymphoblastic leukaemia underwent hematopoietic stem cell transplantation. The patient had reactivation of BKPyV infection and developed an haemorrhagic cystitis. Three months after transplant, BKPyV viremia and viruria increased and she developed a severe nephropathy associated to a polyclonal gammopathy with high levels of isolated IgM.
Conclusion: This case report describes a rare and unexpected polyclonal gammopathy developed during a polyomavirus-associated nephropathy confirmed by immunohistochemical and laboratory analyses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335512 | PMC |
| http://dx.doi.org/10.1186/s12985-015-0254-z | DOI Listing |
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