AI Article Synopsis
- The study compares the effectiveness of two inflammatory biomarkers, procalcitonin (PCT) and C-reactive protein (CRP), for early sepsis detection in patients.
- A total of 138 patients were examined over 7 days, with PCT and CRP levels measured, along with SOFA scores, to classify the severity of their condition.
- The results showed that PCT levels significantly varied across different patient severity groups, while CRP levels did not, indicating that PCT may be a more reliable biomarker for assessing sepsis severity.
Article Abstract
Background: The clinical value of inflammatory biomarkers is still questionable.
Aim Of The Work: The aim of this study is to compare the clinical informative value of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentration in the early detection of sepsis, as well as relating these biomarkers to other scoring systems.
Patients And Methods: A total of 138 patients were enrolled in our study. All were subjected to PCT, CRP, and sequential organ failure assessment (SOFA) scores daily for 7 days (starting from admission day). Blood samples were collected before starting antibiotics, with 28 days follow-up and patients were assigned to three groups: Group I: SOFA 2-7, Group II: SOFA 8-10, and Group III: SOFA ≥11.
Results: Underlying clinical diagnosis revealed pneumonia in 72 patients, urinary tract infections in eight, bloodstream infection in four, and other infections in 23, while infection could not be traced in 25 patients. The mean PCT was 3 ng/ml (95% confidence interval [CI]: 1-4), 12 ng/ml (95% CI: 9.1-14), and 19 ng/ml (95% CI: 16.3-22.3) in Groups I, II, and III, respectively, with a statistically significant difference in the mean PCT level among the three groups (P < 0.0001). On the other hand, CRP mean level did not significantly differentiate between the groups (147.1 mg/L in Group II, which was even higher than the level of Group III, 138.4 mg/L).
Conclusion: PCT seems to do better than CRP in predicting the SOFA groups, giving its patronage display over a wide spectrum of insults.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258970 | PMC |
| http://dx.doi.org/10.4103/0259-1162.143115 | DOI Listing |
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