Multimaterial 3D printing using microfluidic printheads specifically designed for seamless switching between two visco-elastic materials "on-the-fly" during fabrication is demonstrated. This approach opens new avenues for the digital assembly of functional matter with controlled compositional and property gradients at the microscale.

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.201500222DOI Listing

Publication Analysis

Top Keywords

microfluidic printheads
8
multimaterial printing
8
printheads multimaterial
4
printing viscoelastic
4
viscoelastic inks
4
inks multimaterial
4
printing microfluidic
4
printheads designed
4
designed seamless
4
seamless switching
4

Similar Publications

Article Synopsis
  • New 3D bioprinting techniques show potential in tissue engineering but are expensive and less accessible for underfunded labs.
  • A new platform called Microfluidic-assisted Open Source 3D Bioprinting System (MOS3S) is being developed to make bioprinting more affordable and versatile by allowing the use of multiple materials.
  • MOS3S combines advanced print technology with precise control systems to create high-resolution structures for research in disease modeling and tissue regeneration.
View Article and Find Full Text PDF

Droplet-based bioprinting has long struggled with the manipulation and dispensation of individual cells from a printhead, hindering the fabrication of artificial cellular structures with high precision. The integration of modern microfluidic modules into the printhead of a bioprinter is emerging as one approach to overcome this bottleneck. This convergence allows for high-accuracy manipulation and spatial control over placement of cells during printing, and enables the fabrication of cell arrays and hierarchical heterogenous microtissues, opening new applications in bioanalysis and high-throughput screening.

View Article and Find Full Text PDF

Flow cytometric printing of double emulsions into open droplet arrays.

Lab Chip

May 2023

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.

Delivery of double emulsions in air is crucial for their applications in mass spectrometry, bioanalytics, and material synthesis. However, while methods have been developed to generate double emulsions in air, controlled printing of double emulsion droplets has not been achieved yet. In this paper, we present an approach for in-air printing of double emulsions on demand.

View Article and Find Full Text PDF

Millimeter-thick 3D tissues constructed by densely cellularized core-shell microfluidic bioprinting.

Biofabrication

April 2023

Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan.

Recently, microfluidic bioprinting methods, which utilize microfluidic devices as printheads to deposit microfilaments, have improved printing resolution. Despite the precise placement of cells, current efforts have not succeeded in forming densely cellularized tissue within the printed constructs, which is highly desired for the biofabrication of solid-organ tissues with firm tissue consistency. In this paper, we presented a microfluidic bioprinting method to fabricate three dimension tissue constructs consisting of core-shell microfibers where extracellular matrices and cells can be encapsulated within the core of the fibers.

View Article and Find Full Text PDF

Influence of the Volatility of Solvent on the Reproducibility of Droplet Formation in Pharmaceutical Inkjet Printing.

Pharmaceutics

January 2023

Microfluidics, Faculty of Mechanical Engineering and Marine Technology, University of Rostock, Justus-von-Liebig Weg 6, 18059 Rostock, Germany.

Drop-on-demand (DOD) inkjet printing enables exact dispensing and positioning of single droplets in the picoliter range. In this study, we investigate the long-term reproducibility of droplet formation of piezoelectric inkjet printed drug solutions using solvents with different volatilities. We found inkjet printability of EtOH/ASA drug solutions is limited, as there is a rapid forming of drug deposits on the nozzle of the printhead because of fast solvent evaporation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!