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An unusual cause of inappropriate shocks delivered by an implantable cardioverter defibrillator.
BMC Cardiovasc Disord
July 2024
Christian-Albrechts-Universität, Medizinische Fakultät, Christian-Albrechts-Platz 4, 24118, Kiel, Germany.
Introduction: Cardiac implantable electronic device (CIED) complications present significant challenges in clinical practice, especially in elderly patients with multiple comorbidities. Common adverse events include infection, lead malfunction, and device migration. Twiddler's Syndrome, a rare but serious CIED complication characterised by patient manipulation causing lead displacement and device malfunction, is often underreported.
View Article and Find Full Text PDFCost-effectiveness of taurolidine-citrate in a cohort of patients with intestinal failure receiving home parenteral nutrition.
JPEN J Parenter Enteral Nutr
February 2024
Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Woolloongabba, Brisbane, Queensland, Australia.
Background: Catheter-related bloodstream infections (CRBSIs) in patients receiving home parenteral nutrition (HPN) for chronic intestinal failure (CIF) are associated with significant morbidity and financial costs. Taurolidine is associated with a reduction in bloodstream infections, with limited information on the cost-effectiveness as the primary prevention. This study aimed to determine the cost-effectiveness of using taurolidine-citrate for the primary prevention of CRBSIs within a quaternary hospital.
View Article and Find Full Text PDFCost-utility analysis of 4% tetrasodium ethylenediaminetetraacetic acid, taurolidine, and heparin lock to prevent central line-associated bloodstream infections in children with intestinal failure.
JPEN J Parenter Enteral Nutr
January 2024
Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Article Synopsis
- Central line-associated bloodstream infections (CLABSI) are a critical issue for children with intestinal failure, prompting a study to compare the cost-effectiveness of 4% tetrasodium EDTA against taurolidine and heparin.
- A Markov cohort model simulated outcomes for a 1-year-old child with intestinal failure over a 17-year period, measuring quality-adjusted life-years (QALYs) and costs.
- The results showed that 4% tetrasodium EDTA was more effective and less expensive, yielding savings and additional QALYs compared to both taurolidine and heparin, suggesting it as the optimal treatment strategy.
Prophylactic antibiotics for preventing gram-positive infections associated with long-term central venous catheters in adults and children receiving treatment for cancer.
Cochrane Database Syst Rev
October 2021
Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Article Synopsis
- This review focuses on the use of long-term central venous catheters (CVCs) in cancer treatment, highlighting the issue of infections, primarily caused by gram-positive bacteria, despite adherence to sterile practices.
- The main objective is to evaluate the effectiveness of prophylactic antibiotics to prevent these infections during the insertion of CVCs or through antimicrobial flush solutions in both adults and children with cancer.
- The review involved a thorough search of various medical databases and included randomized controlled trials that compared antibiotic administration with non-antibiotic alternatives for preventing gram-positive infections related to CVCs.
A systematic review of preclinical studies on the efficacy of taurine for the treatment of rheumatoid arthritis.
Amino Acids
June 2021
Department of Health Education and Promotion, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
Due to the undesirable effects of conventional medical therapies prescribed for rheumatoid arthritis (RA), complementary therapies, especially nutritional agents, have recently gained great attention. Recent animal and in vitro researches have shown benefits of taurine (Tau), a sulfur-containing amino acid, in RA and suggest that Tau may be a therapeutic candidate in RA; however, no systematic review exists regarding Tau and RA. Accordingly, this paper systematically reviewed the available researches regarding Tau and RA and plausible underlying mechanisms.
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