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Comparative healthcare costs in patients with metastatic melanoma in the USA. | LitMetric

Comparative healthcare costs in patients with metastatic melanoma in the USA.

Melanoma Res

aIMS Health Inc., Plymouth Meeting, Pennsylvania bGenentech Inc., South San Francisco, California, USA.

Published: August 2015

AI Article Synopsis

  • A study analyzed treatment costs and adverse events for metastatic melanoma patients using a large claims database, comparing five different drugs: vemurafenib (VEM), ipilimumab (IPI), dacarbazine (DTIC), paclitaxel (PAC), and temozolomide (TMZ).
  • The total mean all-cause costs per treatment episode were found to be highest for IPI ($153,062), followed by VEM ($77,687), with DTIC, TMZ, and PAC costing significantly less.
  • Findings showed that VEM had lower monthly treatment and adverse event costs compared to IPI and was comparable to other treatments, aiding in decisions for clinicians and policymakers in managing metastatic melanoma.

Article Abstract

Recent advances have increased treatment options for, and improved clinical outcomes in, metastatic melanoma (mM). Using a large claims database, this retrospective study compared healthcare and adverse event (AE) costs in a US managed care population of mM patients initiating vemurafenib (VEM), ipilimumab (IPI), dacarbazine (DTIC), paclitaxel (PAC), or temozolomide (TMZ) from July 2009 to September 2012. Treatment episodes were identified from the start of study drugs (index date) to a switch to a different study drug, or a gap greater than 45 days (>112 days for IPI). Grade 3/4 adverse events occurring ≥5% from study drug package inserts were selected for this analysis. All-cause costs for treatment episodes and AEs were normalized as monthly costs. Generalized estimating equation models with log link and gamma distribution provided adjusted monthly treatment episode and AE costs. A total of 809 treatment episodes were identified in 541 mM patients, with a mean (SD) age of 57.5 (11.5) years. The total mean (SD) all-cause cost per treatment episode for VEM was $77 687 ($60 329), for IPI was $153 062 ($134 048), for DTIC was $35 243 ($33 641), for TMZ was $42 870 ($41 384), and for PAC was $58 991 ($81 306). The adjusted mean monthly treatment episode cost for VEM was significantly lower than that for IPI and comparable to that for other drugs. VEM had a significantly lower monthly AE cost than IPI, DTIC, and PAC. In combination with safety and efficacy findings, these results may assist clinicians, patients, policy makers, and payers in the treatment of mM.

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Source
http://dx.doi.org/10.1097/CMR.0000000000000159DOI Listing

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