AI Article Synopsis
- LDH is an enzyme present in various body tissues, with its concentration in saliva mainly derived from cells in the oral epithelium, indicating potential cellular damage and a link to oral lesions.
- In a study involving three groups—healthy individuals, patients with oral leukoplakia, and those with oral squamous cell carcinoma—LDH levels were measured to assess differences in enzyme concentration.
- Results showed that salivary LDH levels increased with the severity of oral lesions, indicating a correlation between higher LDH levels and more severe conditions such as OSCC.
Article Abstract
Background: Enzyme Lactate Dehydrogenase (LDH) is found in the cells of almost all body tissues. The profile of salivary total LDH enzymes is similar to that found in oral epithelium, indicating that the major source of salivary LDH is probably the oral epithelium-shedding cells. Consequently, LDH concentration in saliva, as an expression of cellular necrosis, could be a specific indicator for oral lesions that affect the integrity of the oral mucosa.
Materials And Methods: Study comprised of three groups as follows: Group I: Comprised of 25 healthy individuals of comparable age. Group II: 25 otherwise healthy and consenting patients with oral leukoplakia (OL). Group III: 25 otherwise healthy and consenting oral squamous cell carcinoma (OSCC) patients. Biochemical estimation of LDH was done with the help of Semiautomatic Analyzer.
Results: Inter comparison of salivary total LDH levels between all the three groups revealed that salivary LDH levels increase from healthy control group to Oral Leukoplakia group to further increase in OSCC group. On comparisons between the histopathological grades of OSCC group the level of LDH were found to increase from well differentiated to moderately differentiated to further increase in poorly differentiated patients.
Conclusion: The present salivary analysis for LDH enzyme reveals an overall altered salivary LDH enzyme level in OL and OSCC cases.
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| http://dx.doi.org/10.4103/0973-1482.138193 | DOI Listing |
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