Understanding the evolutionary relationships between species could help researchers select better model organisms to study in the laboratory.
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| http://dx.doi.org/10.7554/eLife.07431 | DOI Listing |
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Institute of Inorganic and Analytical Chemistry, Justus Liebig University Giessen, Giessen 35392, Germany.
Fascioliasis, a zoonotic disease caused by liver flukes of the genus , poses significant health threats to both humans and livestock. While some infections remain asymptomatic, others can lead to fatal outcomes, particularly during the acute phase characterized by the migration of immature parasites causing severe liver damage. Through the combination of data acquired via high-spatial-resolution atmospheric-pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging (AP-SMALDI MSI) and nanohydrophilic interaction chromatography tandem mass spectrometry, we investigated glycosphingolipids (GSLs) in both adult and immature parasite stages as well as the host liver and bile duct to unravel the intricacies of the host-pathogen interplay and associated pathology.
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- C. elegans, a small, translucent nematode, is used as a model organism for biomedical research due to its simple structure and short life cycle, allowing insights into genetics, development, and aging.
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Anisakis extracellular vesicles elicit immunomodulatory and potentially tumorigenic outcomes on human intestinal organoids.
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Fasciola hepatica and Dicrocoelium dendriticum are parasitic trematodes residing in the bile ducts of mammalian hosts, causing, in some cases, impairment of liver function and hepatic fibrosis. Previous studies have shown that extracellular vesicles released by F. hepatica (FhEVs) and D.
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