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A Review on Mitotane: A Target Therapy in Adrenocortical Carcinoma.
Cancers (Basel)
December 2024
Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.
Adrenocortical carcinomas (ACCs) are rare and aggressive malignancies of adrenal cortex, associated with largely unknown mechanisms of biological development and poor prognosis. Currently, mitotane is the sole approved drug for treating advanced adrenocortical carcinomas (ACCs) and is being utilized more frequently as postoperative adjuvant therapy. Although it is understood that mitotane targets the adrenal cortex and disrupts steroid production, its precise mechanism of action requires further exploration.
View Article and Find Full Text PDFLong-survival of a patient with esophageal cancer benefited from comprehensive treatment and MDT: a case report.
J Thorac Dis
November 2024
Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
Background: Immune checkpoint inhibitors (ICIs) are emerging as important drugs for patients with locally advanced esophageal cancer (EC). Yet, immune-related adverse events (irAEs) may be a major obstacle for these population. Multidisciplinary team (MDT) is an efficient way to deal with such conditions.
View Article and Find Full Text PDFFurther characterization of adrenocortical and thyroid hormone concentrations of leatherback turtles () under various stressors, including validation of a plasma aldosterone assay.
Conserv Physiol
December 2024
Anderson Cabot Center for Ocean Life, New England Aquarium, 1 Central Wharf, Boston, MA 02110, USA.
Leatherback turtles () are endangered by anthropogenic threats. Characterizing the physiologic response of leatherback turtles under various stressors may inform conservation strategies. In this study, a commercially available enzyme immunoassay for aldosterone was validated for leatherback turtle plasma, and it was used with previously validated assays for corticosterone and free thyroxine (fT4) to evaluate the physiologic status of leatherback turtles that were entangled in fishing gear, stranded on shore, nesting or intentionally captured at sea during ecologic studies.
View Article and Find Full Text PDFSynchronous bilateral adrenalectomy for ACTH-independent Cushing's syndrome in children: multidisciplinary management.
Eur J Endocrinol
November 2024
Department of Pediatric Surgery and Urology, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, 149 Rue de Sèvres, 75015 Paris, France.
Objective: Adreno CorticoTropic Hormone (ACTH)-independent Cushing's syndrome (CS) in children is very rare but potentially fatal. In bilateral nodular hyperplasia, synchronous bilateral adrenalectomy (SBA) represents the definitive treatment to correct hypercortisolism. We aim to report the multidisciplinary management of this rare condition.
View Article and Find Full Text PDFPolystyrene microplastics disrupt adrenal steroid synthesis in male mice via mitochondrial dysfunction.
Ecotoxicol Environ Saf
December 2024
Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China. Electronic address:
Microplastics have gained significant social attention, as they can enter our bodies through food and drinking water. The adrenal gland is essential for the maintenance of metabolic homeostasis and stress responses. Nevertheless, the effects of microplastics on the steroid synthesis in the adrenal cortex was still unclear.
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