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Similar Publications
Recurrent fusion transcripts detected by whole-transcriptome sequencing of 120 primary breast cancer samples.
Genes Chromosomes Cancer
November 2015
Department of Surgery, Seoul National University Hospital, Seoul, Korea.
Article Synopsis
- The study analyzed 120 primary breast cancer samples and adjacent normal tissues using whole-transcriptome sequencing to discover new gene fusion transcripts linked to breast cancer.* -
- Out of thousands of potential fusions detected, the researchers focused on those found in HER2 subtype cancers and validated 32 out of 70 candidates, including six recurrent fusions.* -
- Notably, a novel fusion called EEF1DP3-FRY was identified in about 6.7% of the samples and is believed to cause early termination of the FRY gene, which is important for cell structure during division.*
MAGI3-AKT3 fusion in breast cancer amended.
Nature
April 2015
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York 10065, USA.
Sequence analysis of mutations and translocations across breast cancer subtypes.
Nature
June 2012
The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with an estimated 1.38 million new cases and 458,000 deaths in 2008 alone. This malignancy represents a heterogeneous group of tumours with characteristic molecular features, prognosis and responses to available therapy.
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