Purpose: To evaluate the demographic, etiologic, and clinical characteristics of open globe injuries in preschool children.
Methods: The medical files of preschool children who had an operation for an open globe injury from January 2003 to January 2013 were retrospectively analyzed. The patients' demographics and injury characteristics were recorded.
Results: The study consisted of 44 preschool children with an open globe injury. The mean age was 4.38 ± 1.39 years. Most of the injuries occurred in boys (32/44). All patients were followed up for at least 3 months (mean, 8.47 ± 6.38 months; range, 3-24 months). The mean time between injury and operation was 10.40 ± 5.94 hours. Injuries happened most frequently at home (45.4%), and the most common cause of injury was kitchen items (25%). The final visual acuity could be evaluated only in 21 patients, and 90.4% of them had residual vision deficit.
Conclusions: Because open globe injuries occur most frequently at home or in the immediate surroundings of the house, higher awareness of parents and child care providers is extremely important to prevent these injuries in preschool children.
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http://dx.doi.org/10.1097/PEC.0000000000000433 | DOI Listing |
Background: Overexpression of tear matrix metalloproteinases-9 (MMP-9) on the ocular surface tissues has been reported to result in ocular surface damage. MMP-9 levels in tears have been listed as one of many tools for confirming dry eye disease (DED).
Objective: This investigation aimed to compare MMP-9 levels and ocular surface parameters in diabetic patients with and without DED.
Ophthalmol Glaucoma
January 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China; State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032, China. Electronic address:
Purpose: Liver disease is associated with a range of extrahepatic complications, which have recently been expanded to include ophthalmic conditions. However, evidence is lacking regarding its impact on primary open-angle glaucoma (POAG). This study aimed to investigate whether major liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), alcoholic liver disease (ALD), viral hepatitis, and liver fibrosis and cirrhosis, were associated with POAG.
View Article and Find Full Text PDFProg Neurobiol
January 2025
Section on Cognitive Neurophysiology and Imaging, National Institute of Mental Health; Bethesda, MD, USA; Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Eye Institute; Bethesda, MD, USA. Electronic address:
The macaque cerebral cortex contains concentrations of neurons that prefer faces over inanimate objects. Although these so-called face patches are thought to be specialized for the analysis of facial signals, their exact tuning properties remain unclear. For example, what happens when an object by chance resembles a face? Everyday objects can sometimes, through the accidental positioning of their internal components, appear as faces.
View Article and Find Full Text PDFJ Feline Med Surg
January 2025
Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Objectives: To investigate the pathogenicity of feline herpesvirus-1 (FHV-1) to the cornea, FHV-1 strains isolated from feline eyes with dendritic ulcers were subjected to genomic analysis to determine whether FHV-1 vaccine strains are involved in the formation of dendritic ulcers.
Methods: All open reading frame (ORF) sequences of the three F2 strains (Virbac, Intervet and Merial) and the FHV-1 clinical isolates from cats registered in GenBank were compared to detect nucleotide variants unique to the F2 strains, with those nucleotides then being used for simple genotyping of the F2 strains. In all isolates from feline eyes with dendritic ulcers, the regions including nucleotide variants of the F2 strain were amplified with PCR and sequenced.
Alzheimers Dement
December 2024
CellSight Ocular Stem Cell and Regeneration Program, Sue Anschutz-Rodgers Eye Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
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