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Long-term effect of molsidomine, a direct nitric oxide donor, as an add-on treatment, on endothelial dysfunction in patients with stable angina pectoris undergoing percutaneous coronary intervention: results of the MEDCOR trial. | LitMetric

AI Article Synopsis

  • The MEDCOR trial evaluates the effectiveness of molsidomine, a nitric oxide donor, in enhancing endothelial function in stable angina patients after percutaneous coronary intervention over a year.
  • Results showed that while changes in overall endothelial function did not significantly differ between molsidomine and placebo, molsidomine did lead to a notable decrease in the MPO activity/antigen ratio.
  • Ultimately, the trial concluded that molsidomine did not show major advantages over placebo, except for the specific decrease in MPO activity, indicating some potential benefits in this regard.

Article Abstract

Objective: The MEDCOR trial is a double-blind, randomized study aiming at demonstrating the superiority of molsidomine (direct NO donor) over placebo, used as add-on treatments, on improving endothelial function (EF) after 12 months, in stable angina patients undergoing percutaneous coronary intervention.

Methods: EF was assessed by peripheral vasodilator response (i.e. Endoscore) using arterial tonometry and by several biomarkers, in terms of changes versus baseline after a one-year treatment.

Results: The change in Endoscore was +75 ± 130% in placebo group and +39 ± 145% in molsidomine group (p = 0.143). There was a decrease in sICAM-1 with molsidomine (-6%) and an increase with placebo (+6%). The MPO activity/antigen ratio slightly increased with placebo (+9%) and strongly decreased with molsidomine (-42%) (p = 0.020).

Conclusion: The MEDCOR trial was not able to demonstrate significant differences between molsidomine and placebo for all parameters, except the MPO activity/antigen ratio which significantly decreased with molsidomine (p = 0.020 versus placebo).

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Source
http://dx.doi.org/10.1016/j.atherosclerosis.2015.03.045DOI Listing

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