A nanoparticle design featuring pH-responsive alkoxyphenyl acylsulfonamide ligands is reported herein. As a result of ligand structure, this nanoparticle is neutral at pH 7.4, becoming positively charged at tumor pH (<6.5). The particle uptake and cytotoxicity increase over this pH range. This pH-controlled uptake and toxicity makes this particle a promising tool for tumor selective therapy.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484729 | PMC |
| http://dx.doi.org/10.1002/anie.201411615 | DOI Listing |
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