Background: There are no available data on the healing process at the bone-implant interface after immediate implant placement.
Purpose: This study aimed to establish an animal experimental model of titanium implants placed in mouse maxillae and compare the healing pattern of the bone-implant interface after immediate implant placement with that after delayed implant placement.
Materials And Methods: Maxillary first molars (M1) from 4-week-old mice were extracted and replaced with the implant following drilling (immediate-placement group). In contrast, M1 from 2-week-old mice were extracted, followed by drilling and implantation after 4 weeks (delayed-placement group). The decalcified samples at 0-28 days after implantation were processed by immunohistochemistry, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay, and tartrate-resistant acid phosphatase histochemistry. The elements and bone volume of undecalcified samples were quantitatively analyzed by an electron probe microanalyzer.
Results: Osseointegration was completed by 28 days after the procedure in both groups. There were no differences in contact area, bone loss at the cervical area, or rate of calcification at the bone-implant interface between the two groups.
Conclusions: This study found no significant differences in the chronological healing process at the bone-implant interface between the two groups at the cellular level.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/cid.12280 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
3D-Printed Prosthesis with an Articular Interface for Anatomical Acetabular Reconstruction After Type I + II (+ III) Internal Hemipelvectomy: Clinical Outcomes and Finite Element Analysis.
J Bone Joint Surg Am
October 2024
Musculoskeletal Tumor Center, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Background: Pelvic reconstruction after type I + II (or type I + II + III) internal hemipelvectomy with extensive ilium removal is a great challenge. In an attempt to anatomically reconstruct the hip rotation center (HRC) and achieve a low mechanical failure rate, a custom-made, 3D-printed prosthesis with a porous articular interface was developed. The aim of this study was to investigate the clinical outcomes of patients treated with this prosthesis.
View Article and Find Full Text PDFA Micro-CT Based Cadaveric Study Investigating Bone Density Changes During Hip Arthroplasty Surgery.
J Orthop Res
December 2024
WMG, University of Warwick, Coventry, UK.
The impact of broaching and uncemented implantation on bone density during total hip arthroplasty (THA) remains unclear. Previous studies have typically examined extracted bone sections, which may not directly correlate with outcomes in human hip systems. This study aimed to evaluate bone density changes resulting from broaching and uncemented implantation using micro-computed tomography (μCT) on cadaveric samples.
View Article and Find Full Text PDFBackground: The cementation technique is crucial for achieving adequate fixation and optimal survivorship in total knee arthroplasty (TKA). The thickness of the cement at the tibial bone-implant surface may be related to aseptic tibial loosening. However, to date, no studies have demonstrated a direct association between cement thickness and rates of aseptic tibial loosening.
View Article and Find Full Text PDFDynamics of Mucosal Integration of Machined versus Anodized Titanium Implants.
J Dent Res
December 2024
Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
The long-term success of dental implants depends on the ability of soft tissues to form a protective barrier, limiting pathogen infiltration into peri-implant tissues. Here, we investigated the impact of an anodized surface modification on mucosal integration. Scanning electron microscopy and surface chemistry characterization were carried out on miniaturized implants.
View Article and Find Full Text PDFRemodel Heterogeneous Electrical Microenvironment at Nano-Scale Interface Optimizes Osteogenesis by Coupling of Immunomodulation and Angiogenesis.
Small
December 2024
Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Immunomodulation is essential for implants to regulate tissue regeneration, while bioelectricity plays a fundamental role in regulating immune activities. Under natural preferences, the bone matrix electrical microenvironment is heterogeneous in the nanoscale, which provides fundamental electrical cues to regulate bone immunity and regenerative repair. However, remodeling bone nanoscale heterogeneous electrical microenvironment remains a challenge, and the underlying immune modulation mechanism remains to be explored.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!