The lipid-lowering, fibrinolytic, and anticoagulant effects of leucine-containing glyprolines, Pro-Gly-Pro-Leu and Leu-Pro-Gly-Pro, were studied in vitro in the blood of patients with disorders of lipid metabolism. The lipid-lowering impact of glyprolines and their ability to reduce the polymerization and to increase the depolymerization of fibrin in human blood were found. Possible mechanisms of lipolytic action of peptides by means of modulation of the lipid-dependent phospholipase A2 were proposed.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Management of people after stroke in 383 Victorian general practices, 2014-2018: analysis of linked stroke registry and general practice data.
Med J Aust
November 2024
Monash Health, Monash University, Melbourne, VIC.
Objective: To evaluate the management in Victorian general practice of people who have been hospitalised with stroke or transient ischaemic attacks (TIA).
Study Design: Retrospective observational study; analysis of linked Australian Stroke Clinical Registry (AuSCR) and general practice data.
Setting: 383 general practices in the Eastern Melbourne, South Eastern Melbourne, and Gippsland primary health networks (Victoria), 1 January 2014 - 31 December 2018.
Acute Limb Ischemia Management and Complications: From Catheter-Directed Thrombolysis to Long-Term Follow-up.
Cardiol Rev
August 2024
Departments of Cardiology and Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY.
Article Synopsis
- Acute limb ischemia (ALI) is a medical emergency that requires rapid diagnosis and treatment to avoid permanent tissue damage and potential amputation.
- Catheter-directed thrombolysis is considered a treatment for mild to moderate ALI but can lead to higher risks of complications, such as distal embolization and bleeding events compared to surgical options.
- Postoperative care for ALI patients is crucial and should include monitoring for compartment syndrome, managing cardiovascular risks, and conducting follow-up evaluations to ensure optimal recovery outcomes.
Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Rev Cardiovasc Med
August 2023
School of Rehabilitation Medicine, Henan University of Chinese Medicine, 450046 Zhengzhou, Henan, China.
Background: As a fibrinolytic enzyme from fermented soybean, nattokinase has been shown to be potentially beneficial for cardiovascular health, but current clinical evidences regarding the nattokinase supplementation on cardiovascular risk factors are various. This study aims to evaluate the cardiovascular efficacy of nattokinase.
Methods: Four electronic databases were systematically searched to collect eligible randomized controlled trials.
Determinants of adherence to post-stroke/transient ischemic attack secondary prevention medications: A cohort study.
Eur J Neurol
October 2024
Research on Healthcare Performance RESHAPE, INSERM U1290, Université Claude Bernard Lyon 1, Lyon, France.
Article Synopsis
- The study focused on measuring how well patients adhered to medications that prevent future strokes during the three years following an ischemic stroke or TIA.
- Key findings indicated that 61% to 65% of patients had optimal adherence over the three years.
- Factors influencing adherence included education level, where higher education increased adherence, and depression, which also negatively impacted adherence rates.
Long-Term Drug Therapy Following Carotid Endarterectomy Aimed at Reducing Major Adverse Cardiovascular Events.
Ann Vasc Surg
September 2024
Department of Vascular Surgery, Royal Free London NHS Foundation Trust, London, UK.
Background: Timely carotid endarterectomy (CEA) reduces the risk of future stroke. This benefit is maximized with lifelong drug therapy aimed at reducing further major adverse cardiovascular events (MACEs), including stroke. Studies suggest that around half discontinue these drugs within 12 months.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!