AI Article Synopsis
- The review discusses recent advancements in understanding how the nervous and immune systems interact to influence cancer-related pain.
- It highlights that various signaling pathways and immune cell types play a role in pain caused by cancer and its treatments, along with changes in neuron functions in cancer pain.
- Identifying these cellular processes could lead to new drug development and better pain management for cancer patients.
Article Abstract
Purpose Of Review: The current review provides a summary of recent advances in our understanding of the neuroimmune interactions which influence the development of pain associated with cancer.
Recent Findings: Common signalling pathways, mediators and immune cell types are involved in the generation of pain as a result of both cancer and its treatment. Distinct alterations in central and peripheral neuronal function occur in multiple forms of cancer pain. Other more unusual neuroimmune processes such as graft-versus-host disease may cause cancer pain.
Summary: Identification of the cellular processes which underlie the generation of cancer pain provide potential novel targets for drug development and may eventually lead to improved pain management for cancer patients.
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| http://dx.doi.org/10.1097/SPC.0000000000000140 | DOI Listing |
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