Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405739 | PMC |
| http://dx.doi.org/10.1113/JP270328 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Na1.5 and Rac1 on the Epithelial-Mesenchymal Transition in Breast Cancer.
Cell Biochem Biophys
December 2024
First-Class Discipline Team of Kunming Medical University, Third Department of Breast Surgery, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118, China.
Breast cancer is a disease that seriously endangers the health of women. However, it is difficult to treat due to the emergence of metastasis and drug resistance. Exploring the metastasis mechanism of breast cancer is helpful to aim for the appropriate target.
View Article and Find Full Text PDFGlutamine metabolism is essential for coronavirus replication in host cells and in mice.
J Biol Chem
December 2024
Department of Molecular Medicine, Cornell University, Ithaca, New York, USA; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA. Electronic address:
Understanding the fundamental biochemical and metabolic requirements for the replication of coronaviruses within infected cells is of notable interest for the development of broad-based therapeutic strategies, given the likelihood of the emergence of new pandemic-potential virus species, as well as future variants of SARS-CoV-2. Here we demonstrate members of the glutaminase family of enzymes (GLS and GLS2), which catalyze the hydrolysis of glutamine to glutamate (i.e.
View Article and Find Full Text PDFCX43-mediated mitochondrial transfer maintains stemness of KG-1a leukemia stem cells through metabolic remodeling.
Stem Cell Res Ther
December 2024
Department of Hematology Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China.
Background: Acute myeloid leukemia (AML) is characterized by abundant immature myeloid cells, relapse and refractory due to leukemia stem cells (LSCs). Bone marrow mesenchymal stem/ stromal cells (BMSCs) supported LSCs survival, meanwhile, chemotherapy improved connexin43 (CX43) expression. CX43, as the most intercellular gap junction, facilitated transmit mitochondria from BMSCs into AML.
View Article and Find Full Text PDFExosomal miR-129-2-3p promotes airway epithelial barrier disruption in PM-aggravated asthma.
J Environ Manage
November 2024
Department of Environmental Health, School of Public Health, Shanxi Medical University, China; Center for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, China; MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, China. Electronic address:
Particulate matter 2.5 (PM) exposure is intricately linked to asthma exacerbations. Damage to the airway epithelial barrier function serves as an initiating factor for asthma attacks and worsening symptoms.
View Article and Find Full Text PDFArticle Synopsis
- * Research shows that metabolic disorders like obesity and type 2 diabetes worsen the aggressiveness of TNBC, particularly through the influence of circulating plasma exosomes that alter the tumor microenvironment.
- * The study uncovers how plasma exosomes from obese, diabetic patients can induce features in TNBC cells that promote migration and metastasis, along with identifying potential therapeutic targets related to protein activation in TNBC.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!