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| http://dx.doi.org/10.1113/jphysiol.2014.284364 | DOI Listing |
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Nervous system contributions to small cell lung cancer: Lessons from diverse oncological studies.
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Thoracic Oncology Ward, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; Department of Radiotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Clinical Cell Therapy, West China Hospital, Sichuan University, Chengdu, China. Electronic address:
The nervous system plays a vital role throughout the entire lifecycle and it may regulate the formation, development and metastasis of tumors. Small cell lung cancer is a typical neuroendocrine tumor, and it is naturally equipped with neurotropism. In this review, we firstly summarize current preclinical and clinical evidence to demonstrate the reciprocal crosstalk among the nervous system, tumor, and tumor microenvironment in various ways, including neurotransmitter-receptor pathways, innervations of nerve fibers, different types of synapse formation by neurons, astrocytes, and cancer cells, neoneurogenesis.
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Diabetic kidney disease (DKD), one of the most prevalent microvascular complications of diabetes, arises from dysregulated glucose and lipid metabolism induced by hyperglycemia, resulting in the deterioration of renal cells such as podocytes and tubular epithelial cells. Programmed cell death (PCD), comprising apoptosis, autophagy, ferroptosis, pyroptosis, and necroptosis, represents a spectrum of cell demise processes intricately governed by genetic mechanisms in vivo. Under physiological conditions, PCD facilitates the turnover of cellular populations and serves as a protective mechanism to eliminate impaired podocytes or tubular epithelial cells, thereby preserving renal tissue homeostasis amidst hyperglycemic stress.
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Nowadays, metasurfaces have attracted considerable attention due to their promising and advanced control of electromagnetic (EM) waves. However, it is still challenging to shape guided waves into desired free-space mode, while simultaneously manipulating spatial incident waves using a single metasurface. Herein, a class of metasurfaces capable of multiplexing guided and space waves is proposed to achieve advanced EM functionalities in microwave regions, which can find great application potentials in radar systems, wireless communications, and wireless power transfer (WPT).
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