Drawing inspiration from real world interacting systems, we study a system consisting of two networks that exhibit antagonistic and dependent interactions. By antagonistic and dependent interactions we mean that a proportion of functional nodes in a network cause failure of nodes in the other, while failure of nodes in the other results in failure of links in the first. In contrast to interdependent networks, which can exhibit first-order phase transitions, we find that the phase transitions in such networks are continuous. Our analysis shows that, compared to an isolated network, the system is more robust against random attacks. Surprisingly, we observe a region in the parameter space where the giant connected components of both networks start oscillating. Furthermore, we find that for Erdős-Rényi and scale-free networks the system oscillates only when the dependence and antagonism between the two networks are very high. We believe that this study can further our understanding of real world interacting systems.
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http://dx.doi.org/10.1103/PhysRevE.91.032805 | DOI Listing |
J Invertebr Pathol
January 2025
UK Centre for Ecology & Hydrology, Maclean Building, Benson Lane, Crowmarsh Gifford, Wallingford, Oxfordshire OX10 8BB, United Kingdom. Electronic address:
The insect mass-rearing industry to produce feed and food is expanding rapidly. Insects in production frequently encounter multiple pathogens and environmental stressors simultaneously, which can lead to significant economic losses. Our understanding of the interactions between different stressors remains limited, and existing methods primarily focus on determining overall patterns of additivity, synergism, or antagonism.
View Article and Find Full Text PDFBioorg Med Chem
January 2025
Bikai Union Laboratory, Shenyang Pharmaceutical University, Shenyang 110016, China; Hainan Bikai Pharmaceutical Co., LTD, Hainan 570216, China. Electronic address:
The NMDA receptor has long attracted researchers' attention due to its potential as a drug target and its central role in the central nervous system. The NMDA receptor is a ligand-gated and voltage-dependent ion channel widely distributed in the central nervous system. In this study, we employed a drug design strategy combining "molecular assembly" and "combinatorial chemistry.
View Article and Find Full Text PDFGait Posture
December 2024
School of Health and Exercise Sciences, The University of British Columbia Okanagan, Kelowna, British Columbia, Canada. Electronic address:
Background: To maintain standing balance, vestibular cues are processed and integrated with other sensorimotor signals to produce appropriate motor adjustments. Whole-body vestibular-driven postural responses are context-dependent and transformed based upon head and foot posture. Previous reports indicate the importance of intrinsic foot muscles during standing, but it is unclear how vestibular-driven responses of these muscles are modulated by alterations in stability and head posture.
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2025
Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin 541004, China; Guangxi Collaborative Innovation Center for Water Pollution Control and Water Safety Guarantee in Karst Region.
The prevalence of nanoplastics (NPs) and sulfonamide antibiotics (SAs) in the aquatic environment is potentially harmful to the environment, and these pollutants are often present in the environment in the form of composite ones, thereby introducing more complex effects and hazards to the environment. Therefore, it is crucial to investigate the toxic effects of the individual target pollutants and their mixtures. In this study, we used Scenedesmus obliquus as the test organisms, two types of NPs: polystyrene (PS) and amine-modified (NH-PS), four SAs: sulfapyridine (SPY), sulfamethazine (SMR), sulfamethoxypyridazine (SMP), and sulfamethoxazole (SMZ), and their eight binary mixtures were examined.
View Article and Find Full Text PDFCPT Pharmacometrics Syst Pharmacol
January 2025
Astellas Pharma Inc., Northbrook, Illinois, USA.
The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL-7 and murine IL-12 genes (hIL-7/mIL-12-VV) was demonstrated in CT26.WT-bearing mice. In the CT26.
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