In genetic programming, the size of a solution is typically not specified in advance, and solutions of larger size may have a larger benefit. The flexibility often comes at the cost of the so-called bloat problem: individuals grow without providing additional benefit to the quality of solutions, and the additional elements can block the optimization process. Consequently, problems that are relatively easy to optimize cannot be handled by variable-length evolutionary algorithms. In this article, we analyze different single- and multiobjective algorithms on the sorting problem, a problem that typically lacks independent and additive fitness structures. We complement the theoretical results with comprehensive experiments to indicate the tightness of existing bounds, and to indicate bounds where theoretical results are missing.
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http://dx.doi.org/10.1162/EVCO_a_00149 | DOI Listing |
Development
January 2025
Pediatric Genomics Discovery Program, Departments of Pediatrics and Genetics, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA.
Emerging evidence suggests that the nuclear pore complex can have unique compositions and distinct nucleoporin functions in different cells. Here, we show that Nup107, a key component of the NPC scaffold, varies in expression over development: it is expressed at higher levels in the blastula compared to the gastrula suggesting a critical role prior to gastrulation. We find depletion of Nup107 affects the differentiation of the early germ layers leading to an expansion of the ectoderm at the expense of endoderm and mesoderm.
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January 2025
Department of Biology, Technion - Israel Institute of Technology, Haifa, Israel.
Dendrites are crucial for receiving information into neurons. Sensory experience affects the structure of these tree-like neurites, which, it is assumed, modifies neuronal function, yet the evidence is scarce, and the mechanisms are unknown. To study whether sensory experience affects dendritic morphology, we use the arborized nociceptor PVD neurons, under natural mechanical stimulation induced by physical contacts between individuals.
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January 2025
Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Background: Baculoviruses are ideal biological insecticides, providing long-lasting pest control and environmental benefits. Alphabaculovirus mabrassicae stains, with their broad host range, have been effective in agricultural pest management. Various A.
View Article and Find Full Text PDFHum Brain Mapp
January 2025
Department of Psychology, Concordia University, Montreal, Quebec, Canada.
The cortex and cerebellum are densely connected through reciprocal input/output projections that form segregated circuits. These circuits are shown to differentially connect anterior lobules of the cerebellum to sensorimotor regions, and lobules Crus I and II to prefrontal regions. This differential connectivity pattern leads to the hypothesis that individual differences in structure should be related, especially for connected regions.
View Article and Find Full Text PDFCurr Protoc
January 2025
Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Mesothelioma is a lethal cancer of the serosal lining of the body cavities. Risk factors include environmental and genetic factors. Asbestos exposure is considered the principal environmental risk factor, but other carcinogenic mineral fibers, such as erionite, also have a causal role.
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