AI Article Synopsis
- Acute appendicitis is a rare but serious complication in children with acute leukemia, often diagnosed late due to their immunocompromised state.
- Management is complex, as timely treatment is crucial, and there's a possibility of leukemic cells infiltrating the appendix.
- While some cases may be managed conservatively, most require surgery; the text also discusses a successful case where decitabine was used as a bridging therapy for a child with acute myeloid leukemia.
Article Abstract
Acute appendicitis in children with acute leukemia is uncommon and often recognized late. Immunocompromised host state coupled with the importance of avoiding treatment delays makes management additionally challenging. Leukemic infiltration of the appendix though rare must also be considered. Although successful conservative management has been reported, surgical intervention is required in most cases. We present our experience with acute appendicitis in children with acute leukemia and a case of complete remission of acute myeloid leukemia with a short course of decitabine. Decitabine may serve as bridging therapy in critically ill patients who are unable to undergo intensive chemotherapy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392291 | PMC |
| http://dx.doi.org/10.1016/j.lrr.2015.03.001 | DOI Listing |
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