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Click inspired synthesis of antileishmanial triazolyl O-benzylquercetin glycoconjugates. | LitMetric

Click inspired synthesis of antileishmanial triazolyl O-benzylquercetin glycoconjugates.

Glycoconj J

Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University, Varanasi, 221005, India.

Published: May 2015

AI Article Synopsis

Article Abstract

The 1,3-dipolar cycloaddition of deoxy-azido sugars 1 with O-benzylquercetin alkynes (5-7) to afford regioselective triazole-linked O-benzylquercetin glycoconjugates (8-10) was investigated in the presence of CuI/DIPEA in dichloromethane. All the developed glycoconjugates (8-10) were evaluated for anti-leishmanial activity against the promastigotes and amastigotes of Leishmania donovani. Graphical Abstract Click Inspired Synthesis of Antileishmanial Triazolyl O-Benzylquercetin Glycoconjugates.

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Source
http://dx.doi.org/10.1007/s10719-015-9582-xDOI Listing

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