[Comparative study of clinical features between unilateral and bilateral orbital IgG4-related disease].

Objective: Descriptive and comparative study of patients with orbital IgG4-related disease.

Material And Methods: A review and analysis of the cases diagnosed with inflammatory orbital lesion related to IgG4 by the Ophthalmic Pathology Service in the Dr. Luis Sánchez Bulnes Hospital.

Results: A total of 9 cases were found, in which 66% were women, and with a mean age of 48 years and time to diagnosis of 2 years. Unilateral involvement was observed in 56% of cases. All the females experienced pain, and there was an optimal response to corticosteroid treatment in 100% of patients who required medical treatment (one case showed spontaneous resolution). In bilateral cases (44%), only 25% were female, and none had pain as a presenting symptom. Furthermore, 25% of these patients required a combination with immunosuppressants to control inflammation.

Conclusions: Clinical presentation of patients with unilateral orbital IgG4-related disease differs from those with bilateral involvement.