Mutations in the β-tubulin isotype 1 gene at codons 167 (F167Y), 198 (E198A) and 200 (F200Y) have been associated with benzimidazole resistance in helminths. The F200Y polymorphism has previously been described for Ancylostom caninum; however, the F167Y polymorphism has not been investigated in members of the Ancylostomatidae family. The aim of this study was to screen for the F167Y polymorphism in A. caninum isolates recovered from naturally infected dogs in two Brazilian states. No mutation was observed at codon 167 in the 230 analyzed samples from the two populations; however, it is possible that this change may be present at a low frequency in other populations of the same species. These results highlight the importance of monitoring the genetic basis involved in the drug resistance process.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.vetpar.2015.03.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Widespread occurrence of benzimidazole resistance single nucleotide polymorphisms in the canine hookworm, Ancylostoma caninum, in Australia.
Int J Parasitol
December 2024
Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia; Sydney Institute for Infectious Diseases, The University of Sydney, New South Wales, Australia. Electronic address:
Canine hookworm (Ancylostoma caninum), a gastrointestinal nematode of domestic dogs, principally infects the small intestine of dogs and has the potential to cause zoonotic disease. In greyhounds and pet dogs in the USA, A. caninum has been shown to be resistant to multiple anthelmintics.
View Article and Find Full Text PDFGenotyping of benzimidazole resistance using β-tubulin isotype 1 marker in of sheep and goats in Paraná, Southern Brazil.
J Helminthol
December 2024
Laboratory of Veterinary Clinical Parasitology, Federal University of Parana, UFPR. Rua dos Funcionários, 1540, Cabral. CEP: 80035-050. Curitiba, PR, Brazil.
is one of the most pathogenic gastrointestinal parasites that infect small ruminants. The indiscriminate use of anthelmintics (i.e.
View Article and Find Full Text PDFBenzimidazole Resistance-Associated Mutations in the β-tubulin Gene of Hookworms: A Systematic Review.
Parasitol Res
December 2024
Department of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
There is a growing number of reports on the occurrence of benzimidazole resistance-associated single nucleotide polymorphisms (SNPs) in the β-tubulin isotype 1 gene of various helminths of veterinary, and public health concerns. However, a comprehensive analysis of their occurrence, and their contributions to conferring benzimidazole resistance among hookworms has yet to be done. The objectives of this systematic review are to summarize and synthesize peer-reviewed evidence on the occurrence of these resistance-associated mutations in hookworms, document their geographical distribution, and assess their contributions to conferring phenotypic resistance.
View Article and Find Full Text PDFThe first molecular detection of benzimidazole resistance in Haemonchus contortus from sheep in Hejing and Minfeng counties of Southern Xinjiang.
Parasitol Res
August 2024
College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, 830052, Xinjiang, China.
To understand the benzimidazole (BZ) resistance of Haemonchus contortus in Southern Xinjiang, three single nucleotide polymorphisms (SNPs) designated as F167Y, E198A, and F200Y, in the isotype-1 β-tubulin gene which are associated with BZ resistance, were investigated for H. contortus populations from sheep in Hejing and Minfeng counties of Southern Xinjiang. In brief, a total of 190 H.
View Article and Find Full Text PDFBenzimidazole F167Y polymorphism in the canine hookworm, Ancylostoma caninum: Widespread geographic, seasonal, age, and breed distribution in United States and Canada dogs.
Int J Parasitol Drugs Drug Resist
April 2024
BioVet Inc., Saint-Hyacinthe, Québec, Canada.
Surveillance data for Ancylostoma spp. and the A. caninum benzimidazole treatment resistance associated F167Y polymorphism using molecular diagnostics was obtained in a large population of dogs from the United States and Canada.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!