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What It Takes To Be a Platelet: Evolving Concepts in Platelet Production.
Circ Res
August 2024
Vascular Biology Program, Boston Children's Hospital, Boston, MA (E.C., I.C.B., J.E.I.).
Platelets are among the most abundant cells within the circulation. Given that the platelet lifespan is 7 to 10 days in humans, a constant production of around 100 billion platelets per day is required. Platelet production from precursor cells called megakaryocytes is one of the most enigmatic processes in human biology.
View Article and Find Full Text PDFImmune attack on megakaryocytes in immune thrombocytopenia.
Res Pract Thromb Haemost
January 2024
Section of Internal and Cardiovascular Medicine, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
A State of the Art lecture titled "Immune Attack on Megakaryocytes in ITP: The Role of Megakaryocyte Impairment" was presented at the International Society on Thrombosis and Haemostasis Congress in 2023. Immune thrombocytopenia (ITP) is an acquired autoimmune disorder caused by autoantibodies against platelet surface glycoproteins that provoke increased clearance of circulating platelets, leading to reduced platelet number. However, there is also evidence of a direct effect of antiplatelet autoantibodies on bone marrow megakaryocytes.
View Article and Find Full Text PDFA circulating proplatelet identified in an iron-deficient patient.
Int J Lab Hematol
August 2024
Division of Hematopathology, QEII Health Sciences Centre, Halifax, Nova Scotia, Canada.
GPIbα-filamin A interaction regulates megakaryocyte localization and budding during platelet biogenesis.
Blood
January 2024
Thrombosis Research Group, The Heart Institute, Newtown, NSW, Australia.
Glycoprotein Ibα (GPIbα) is expressed on the surface of platelets and megakaryocytes (MKs) and anchored to the membrane skeleton by filamin A (flnA). Although GPIb and flnA have fundamental roles in platelet biogenesis, the nature of this interaction in megakaryocyte biology remains ill-defined. We generated a mouse model expressing either human wild-type (WT) GPIbα (hGPIbαWT) or a flnA-binding mutant (hGPIbαFW) and lacking endogenous mouse GPIbα.
View Article and Find Full Text PDFThe role of CREG1 in megakaryocyte maturation and thrombocytopoiesis.
Int J Biol Sci
August 2023
National Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China.
Abnormal megakaryocyte maturation and platelet production lead to platelet-related diseases and impact the dynamic balance between hemostasis and bleeding. Cellular repressor of E1A-stimulated gene 1 (CREG1) is a glycoprotein that promotes tissue differentiation. However, its role in megakaryocytes remains unclear.
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