AI Article Synopsis
- The study evaluated the trivalent seasonal influenza vaccine's effectiveness during the 2014 season in South Africa using a test-negative case-control design with 472 cases and 362 controls.
- The dominant circulating strain was Influenza A(H3N2), and the overall adjusted vaccine effectiveness was estimated at 43.1%, with a wide confidence interval indicating uncertainty.
- The H3N2 viruses from South Africa were primarily in sublineage 3C.3, showing significant differences from the vaccine strain in sublineage 3C.1 due to amino acid changes.
Article Abstract
The effectiveness of the trivalent seasonal influenza vaccine during the 2014 season in South Africa was assessed using a test-negative case-control study design including 472 cases and 362 controls. Influenza A(H3N2) was the dominant strain circulating. The overall vaccine effectiveness estimate, adjusted for age and underlying conditions, was 43·1% (95% CI: -26·8-74·5). 2014 H3N2 viruses from South Africa were mainly in sublineage 3C.3 with accumulation of amino acid changes that differentiate them from the vaccine strain in 3C.1.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474497 | PMC |
| http://dx.doi.org/10.1111/irv.12314 | DOI Listing |
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