The contextual analysis of the primary structures of 28 various dispersed repeats Alu, B1, B2 and L1 (Kpn1) of primates and rodent genomes has been carried out to search for the regions complementary to the 3'-ends of the known at present tRNA of these organisms. It has been shown that the abundance of the investigated repeats contain the regions revealing marked and statistically non-random complementarity to the 3'-end of at least one of the tRNA considered. Taking into account the retroviruses replication model known from literature these revealed regions are considered as potential primer-binding sites for the initiation of reverse transcription of the mentioned repeats or more long DNA fragments containing them.
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J Am Chem Soc
January 2025
Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
Polyethers are versatile materials extensively used in advanced as well as everyday applications. The incorporation of primary amine functionality into polyethers is particularly attractive due to its well-established coupling chemistries. However, the inherent nucleophilicity of amine group poses a challenge in the anionic ring-opening polymerization (ROP) of epoxides and requires the use of robust protecting groups that can withstand the harsh conditions of ROP without triggering undesirable side reactions.
View Article and Find Full Text PDFHypertension
January 2025
Department of Environmental Health, Life Science and Human Technology, Nara Women's University, Japan.
Background: Exposure to cold environments is linked to cold-induced hypertension due to activated sympathetic nerve activity (SNA) and arterial baroreceptor reflex dysfunction. However, direct measurement of SNA during cold-induced hypertension and changes in baroreflex control of SNA remain unexplored.
Methods: Chronically instrumented rats were exposed to cold temperatures (10 °C) over 4 days after a control period (24 °C), and renal and lumbar sympathetic nerve activities were simultaneously measured during cold-induced hypertension.
Front Genet
January 2025
First Clinical School, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Introduction: The deficiency of estrogen correlates with a range of diseases, notably Postmenopausal osteoporosis (PMO) and Parkinson's disease (PD). There is a possibility that PMO and PD may share underlying molecular mechanisms that are pivotal in their development and progression. The objective of this study was to identify critical genes and potential mechanisms associated with PMO by examining co-expressed genes linked to PD.
View Article and Find Full Text PDFCureus
December 2024
Internal Medicine, Hospital Vila Franca de Xira, Vila Franca de Xira, PRT.
Dilated cardiomyopathy (DCM) is a serious condition often leading to acute heart failure (HF), with diverse etiologies including viral myocarditis. This report details a case of reversible DCM in a 34-year-old male who presented with symptoms of acute HF. Diagnostic workup revealed biventricular dilation with severe systolic dysfunction and serology confirming herpes simplex virus infection.
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, Austria.
Background: The reversible splenial lesion syndrome is frequently associated with systemic and central nervous system infections. Whether an infection associated with the occurrence of the reversible splenial lesion syndrome could play a role in the later development of multiple sclerosis is unknown.
Methods: Case Report.
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