Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women followed for up to 20 years. We find that, higher concentrations of the citric acid cycle intermediate, isocitrate, and the bile acid, taurocholate, are associated with lower odds of longevity, defined as attaining 80 years of age. Higher concentrations of isocitrate, but not taurocholate, are also associated with worse cardiovascular health at baseline, as well as risk of future cardiovascular disease and death. None of the metabolites identified are associated with cancer risk. Our findings suggest that some, but not all, metabolic pathways related to human longevity are linked to the risk of common causes of death.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396657 | PMC |
| http://dx.doi.org/10.1038/ncomms7791 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Isatidis root polysaccharides ameliorates post-weaning diarrhea by promoting intestinal health and modulating the gut microbiota in piglets.
Vet Q
December 2025
Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
This study aimed to investigate the effects of dietary isatidis root polysaccharide (IRP) on diarrhea, immunity, and intestinal health in weanling piglets. Forty healthy piglets were randomly assigned to five groups receiving varying dosages of IRP. The findings indicated that different concentrations of IRP significantly reduced diarrhea scores ( < 0.
View Article and Find Full Text PDFPrecise Synthesis of 4.75 V-Tolerant LiCoO with Homogeneous Delithiation and Reduced Internal Strain.
J Am Chem Soc
January 2025
College of Engineering and Applied Sciences, Jiangsu Key Laboratory of Artificial Functional Materials, National Laboratory of Solid State Microstructures, Collaborative Innovation Centre of Advanced Microstructures, Nanjing University, Nanjing 210093, P. R. China.
The rapid advancements in 3C electronic devices necessitate an increase in the charge cutoff voltage of LiCoO to unlock a higher energy density that surpasses the currently available levels. However, the structural devastation and electrochemical decay of LiCoO are significantly exacerbated, particularly at ≥4.5 V, due to the stress concentration caused by more severe lattice expansion and shrinkage, coupled with heterogeneous Li intercalation/deintercalation reactions.
View Article and Find Full Text PDFCrystal Structure, Cation Occupation, and Phase Transitions in Ba(LiNa)NbO Tetragonal Tungsten Bronzes.
Inorg Chem
January 2025
Department of Material Science and Engineering, NTNU Norwegian University of Science and Technology, Trondheim 7491, Norway.
The chemical flexibility of the tetragonal tungsten bronze (TTB) structure offers a large potential for compositional engineering. Cation size and vacancy concentration are known to affect its structure, cation disorder, and functional properties. However, the compositional complexity also makes the TTB structure challenging to understand.
View Article and Find Full Text PDFPotential Air Quality Side-Effects of Emitting HO to Enhance Methane Oxidation as a Climate Solution.
Environ Sci Technol
January 2025
Department of Atmospheric Sciences, University of Utah, Salt Lake City, Utah 84112, United States.
Methane (CH) is a greenhouse gas with a global warming potential 81.2 times higher than carbon dioxide (CO). The intentional emission of oxidants into the atmosphere has been proposed as a geoengineering solution to accelerate the oxidation of CH to CO, thereby reducing surface warming.
View Article and Find Full Text PDFAssociation between serum vitamin D and severe headache or migraine: A population-based analysis.
PLoS One
January 2025
Department of Encephalopathy, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
Background: Vitamin D is thought to play a role in the development of migraine, but the nature of the relationship is still not fully understood. Although some studies have shown an association between vitamin D deficiency and migraine, other studies have had inconsistent or inconclusive results. Therefore, further research is needed to better understand the relationship between vitamin D and migraine headaches.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!