Purpose: To present an overview of clinical evidence of strontium acetate and arginine-based toothpastes, in order to determine which of these substances was the most effective to relieve dentin hypersensitivity (DH).
Methods: An electronic search was performed in PubMed, EMBASE, The Cochrane Library, LILACS, Web of Science and Open Grey databases. The search strategy included MeSH terms, synonyms and keywords with no language or date restriction. Randomized controlled clinical trial studies that compared the effectiveness of arginine/calcium carbonate and strontium acetate toothpaste were included. The risk of bias in the included studies was assessed and classified through the Cochrane Collaboration's common scheme for bias. Data were subgrouped and heterogeneity was tested via comprehensive meta-analysis.
Results: A total of 3,883 potentially relevant studies were identified. After title and abstract examination, only six studies fulfilled the eligibility criteria and were classified as having a "low risk of bias". The majority of studies found better results for arginine/calcium carbonate in comparison with strontium acetate in alleviating DH. Only one study reported superior efficacy of strontium acetate, and only for tactile stimuli, after 8 weeks of home use. The arginine/calcium carbonate-based toothpaste provided a higher level of efficacy in terms of DH relief than the strontium-based toothpaste.
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J Funct Biomater
November 2022
Department of Chemistry, Ribeirão Preto Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-901, Brazil.
Strontium acetate is applied for dental hypersensitivity treatment; however, the use of strontium carbonates for this purpose has not been described. The use of Sr-carbonate nanoparticles takes advantage of both the benefits of strontium on dentin mineralization and the abrasive properties of carbonates. Here in, we aimed to synthesize strontium carbonate and strontium-substituted calcium carbonate nanoparticles and test them as potential compounds in active dentifrices for treating dental hypersensitivity.
View Article and Find Full Text PDFInt J Mol Sci
July 2022
Department of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
Microbial infection and insufficient tissue formation are considered to be the two main causes of dental implant failure. Novel studies have focused on designing dual-functional strategies to promote antibacterial properties and improve tissue cell response simultaneously. In this study, we investigated the antibacterial properties and cytocompatibility of silver nitrate (AgNO) and strontium acetate (SrAc) in a mono-culture setup for dental application.
View Article and Find Full Text PDFBMC Oral Health
October 2021
Department of Research, School of Public Health, Dow University of Health Sciences, Karachi, Pakistan.
Background: Dentin hypersensitivity (DH) is a sharp toothache that influences a patients' oral health-related quality of life. Oral dentifrices have been marketed for pain relief within a minute for DH. The permanent management of DH is being investigated with the remineralisation potential of bioactive agents in dentinal tubules.
View Article and Find Full Text PDFClin Oral Investig
February 2022
Dental Materials Laboratory of the Postgraduate Program in Dentistry, Federal University of Pará, Belém, Pará, Brazil.
Objectives: This study evaluated the effect of photobiomodulation (PBM) combined with 8% strontium acetate (SA8%) in the treatment of dentin hypersensitivity (DH) in non-carious lesions and analyzed the risk factors with the patient's quality of life.
Methods: Eighty teeth with DH were randomly allocated into four treatment groups (n = 20): G1, PBM imitation + toothpaste with no active ingredient; G2, PBM imitation + toothpaste with SA8%; G3, PBM + toothpaste without the active ingredient; and G4, PBM + toothpaste with SA8%. Participants were provided with a questionnaire on the experience of dentin hypersensitivity (QEDH) to assess the impact of desensitizing treatment on health-related quality of life (HRQL).
Microsc Res Tech
January 2022
Department of Microbiology and Virology, Kerman University of Medical Sciences, Kerman, Iran.
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