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Thamnophis sirtalis and their toxic relationship: Testing for intraspecific venom variation in Common Garter Snakes.
Toxicon
January 2025
Department of Biology, University of South Alabama, Mobile, AL 36688, USA. Electronic address:
Intraspecific phenotypic variation can be used as a window into the ecological differences among individuals of a species and lead to a better understanding of adaptive evolution. Adaptive traits, such as venom, that play an important ecological role for a species are useful models for understanding the sources of intraspecific variation. Intraspecific studies on front-fanged venomous snakes have offered deeper insights into the diverse mechanisms and adaptations that support the effectiveness of venom across species.
View Article and Find Full Text PDFEnabling equitable and affordable access to novel therapeutics for pandemic preparedness and response via creative intellectual property agreements.
Wellcome Open Res
July 2024
Drugs for Neglected Diseases initiative (DNDi), Geneva, 1202, Switzerland.
The COVID-19 pandemic demonstrated that the current purely market-driven approaches to drug discovery and development alone are insufficient to drive equitable access to new therapies either in preparation for, or in response to, pandemics. A new global framework driven by equity is under negotiation at the World Health Organization to support pandemic preparedness and response. Some believe that the global intellectual property (IP) system itself is part of the problem and propose a purely Open Science approach.
View Article and Find Full Text PDFToward understanding and enhancing self-determination: a qualitative exploration with autistic adults without co-occurring intellectual disability.
Front Psychiatry
September 2023
Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada.
Article Synopsis
- Self-determination is important for everyone, including Autistic people, but they often face more challenges in achieving it compared to non-autistic people.
- Researchers talked to 19 Autistic adults to understand what self-determination means to them and what helps or hinders them from making choices in life.
- Autistic participants want support that respects their choices, helps them express their true selves, and offers practical help for their unique decision-making styles.
Spontaneous closure of a superior sagittal sinus dural arteriovenous fistula with an extensive angioarchitectural network: A case report and systematic review of the literature.
Surg Neurol Int
July 2023
Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida, United States.
Background: Intracranial dural arteriovenous fistulas (DAVFs) have been documented to occasionally spontaneously regress. However, the mechanism responsible for this occurrence remains speculative.
Methods: We present a case of a Borden II - Cognard IIa+b DAVF involving the superior sagittal sinus (SSS) with bilateral external carotid artery supply that regressed spontaneously.
A pragmatic clinical trial assessing the effect of a targeted notification and clinical support pathway on the diagnostic evaluation and treatment of individuals with left ventricular hypertrophy (NOTIFY-LVH).
Am Heart J
November 2023
Massachusetts General Physicians Organization, Boston, MA; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:
Background: Electronic health records contain vast amounts of cardiovascular data, including potential clues suggesting unrecognized conditions. One important example is the identification of left ventricular hypertrophy (LVH) on echocardiography. If the underlying causes are untreated, individuals are at increased risk of developing clinically significant pathology.
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