Background: Although systemic chemotherapy is inevitably selected as the modality of treatment for high-grade bone and soft tissue sarcoma (BSTS), limited information is available regarding febrile neutropenia (FN).
Patients And Methods: FN incidence, blood culture results and risk factors were analyzed in 35 patients with high-grade BSTS.
Results: FN occurred in 51% of the patients and 24% of the courses of systemic chemotherapy. Culture results indicated pathogen in only 33.3% of patients who had FN. Methicillin-resistant Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus were frequently observed. Body weight of less than 61.0 kg and a tumor originating from the bone in a patient-based analysis, and serum albumin <4.2 g/dl and having a source of infection in a course-based analysis were independent risk factors for FN.
Conclusion: Considerably high risks for FN during chemotherapy for BSTS were confirmed. The risk factors presented here appeared to differ from those in previously reported guidelines.
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