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| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125451 | PLOS |
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Blockchain-enabled digital twin system for brain stroke prediction.
Brain Inform
January 2025
Department of Computing, Glasgow Caledonian University, Glasgow, G4 0BA, Scotland.
A digital twin is a virtual model of a real-world system that updates in real-time. In healthcare, digital twins are gaining popularity for monitoring activities like diet, physical activity, and sleep. However, their application in predicting serious conditions such as heart attacks, brain strokes and cancers remains under investigation, with current research showing limited accuracy in such predictions.
View Article and Find Full Text PDFThe outcome of functional constipation in Saudi children.
Turk J Pediatr
December 2024
Gastroenterology Division, Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Background: Understanding the outcome of functional constipation (FC) for both patients and physicians is essential, yet it has been infrequently reported worldwide. The objective of this report was to update the outcomes of FC in Saudi children.
Methods: Clinical data including age, sex, response to management, duration of follow up, and type of management were collected from the notes of each clinic visits and phone call follow-ups.
Celiac Crisis: A Life-Threatening Complication of Celiac Disease.
Middle East J Dig Dis
October 2024
Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhopal, Madhya Pradesh, India.
Celiac disease (CD) is an immune-mediated enteropathy with varied systemic involvement and association with increased morbidity and mortality. Strong clinical suspicion is the key, and diagnosis is made using histopathology and serology. Though the consumption of a strict gluten-free diet can improve symptoms and limit mucosal damage, curative therapy is still lacking.
View Article and Find Full Text PDFA distinct immunophenotype in children carrying the Blautia enterotype: The generation R study.
Clin Immunol
January 2025
Department of Immunology, Erasmus MC, University Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands; Department of Immunology, Central Clinical School, Monash University and Alfred Hospital, Commercial Road 89, 3004 Melbourne, Victoria, Australia. Electronic address:
Objective: Studies in mouse models and human adults have shown that the intestinal microbiota composition can affect peripheral immune cells. We here examined whether the gut microbiota compositions affect B and T-cell subsets in children.
Methods: The intestinal microbiota was characterized from stool samples of 344 10-year-old children from the Generation R Study by performing 16S rRNA sequencing.
Fatty acid carbon isotopes as tracers of trophic structure and contaminant biomagnification in Arctic marine food webs.
Sci Total Environ
January 2025
Department of Natural Resource Sciences, McGill University, Sainte-Anne-de-Bellevue, QC H9X 3V9, Canada. Electronic address:
Mercury (Hg) and persistent organic pollutant (POP) accumulation among species and biomagnification through food webs is typically assessed using stable isotopes of nitrogen (δN) and carbon (δC) in bulk (whole) tissues. Yet, bulk isotopic approaches have limitations, notably from the potential overlap of isotope values from different dietary sources and from spatial variation in source (baseline) signals. Here, we explore the potential of fatty acid carbon isotopes (FA δC) to (1) evaluate the trophic structure of a marine food web, (2) distinguish feeding patterns among four marine mammal consumers, (3) trace contaminant biomagnification through a food web, and (4) explain interspecific variation in contaminants among high-trophic position predators.
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