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Background: The development and approval of novel drugs are typically time-intensive and expensive. Leveraging a computational drug repurposing framework that integrates disease-relevant genetically regulated gene expression (GReX) and large longitudinal electronic medical record (EMR) databases can expedite the repositioning of existing medications. However, validating computational predictions of the drug repurposing framework remains a challenge.
View Article and Find Full Text PDFCompassionate Use of Omadacycline in a Down Syndrome Pre-Schooler With Critically Ill Atypical Pneumonia Caused by Macrolide-Resistant Mycoplasma Pneumoniae.
Infect Drug Resist
January 2025
Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China.
Background: Rapid and accurate identification of causative organisms and prompt initiation of pathogen-targeted antibiotics are crucial for managing atypical pneumonia. The widespread application of targeted next-generation sequencing (t-NGS) in clinical practice demonstrates significant targeted advantages in rapid and accurate aetiological identification and antimicrobial resistance genes detection, particularly for difficult-to-culture, rare, or unexpected pathogens. An alarming surge of acquired macrolide resistance (MR) in (MP) presents a substantial challenge for the clinical selection of pathogen-targeted antibiotics worldwide, especially for fluoroquinolone-restricted pediatric patients with limited options available.
View Article and Find Full Text PDFRapid introgression of the clubroot resistance gene into cabbage skeleton inbred lines through marker assisted selection.
Mol Breed
February 2025
Key Laboratory of Biology and Genetic Improvement of Horticultural Crops, Ministry of Agriculture, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081 China.
Unlabelled: Clubroot, caused by , is a globally pervasive soil-borne disease that poses a significant challenge primarily in cruciferous crops. However, the scarcity of resistant materials and the intricate genetic mechanisms within cabbage present major obstacles to clubroot resistance (CR) breeding. In our previous research, we developed an Ogura CMS cabbage variety, "17CR3", which harbors the gene, crucial for CR.
View Article and Find Full Text PDFAdvancing healthcare through laboratory on a chip technology: Transforming microorganism identification and diagnostics.
World J Clin Cases
January 2025
Department of Basic Sciences, Biomedical Stomatology Research Group, Universidad de Antioquia U de A, Medellín 0057, Colombia.
In a recent case report in the , emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment outcomes. Laboratory-on-a-chip (LOC) technology has emerged as a transformative tool in health care, offering rapid, sensitive, and specific identification of microorganisms. This editorial provides a comprehensive overview of LOC technology, highlighting its principles, advantages, applications, challenges, and future directions.
View Article and Find Full Text PDF"Having providers who are trained and have empathy is life-saving": Improving primary care communication through thematic analysis with ChatGPT and human expertise.
PEC Innov
June 2025
University of Rhode Island, 142 Flagg Road, Chafee Hall, Department of Psychology, Kingston, RI 02881, USA.
In the rapidly evolving field of healthcare research, Artificial Intelligence (AI) and conversational models like ChatGPT (Conversational Generative Pre-trained Transformer) offer promising tools for data analysis. The aim of this study was to: 1) apply ChatGPT methodology alongside human coding to analyze qualitative health services feedback, and 2) examine healthcare experiences among lesbian, gay, bisexual, transgender, and queer (LGBTQ+) patients ( = 41) to inform future intervention. The hybrid approach facilitated the identification of themes related to affirming care practices, provider education, communicative challenges and successes, and environmental cues.
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