This study aimed to investigate the latent structure of depression with a non-clinical sample of elderly, using taxometric analysis. The latter consists of a family of statistical procedures conceived for testing whether a given psychological construct is best represented by categories or dimensions in which individuals vary. The sample consisted of 570 elderly with a mean age of 71.9 years (SD = 7.45), who answered the Brazilian version of the Geriatric Depression Scale, a cognitive test, and demographic questions. Three taxometric procedures were used: Mean Above Minus Below A Cut (MAMBAC), Maximum Eigenvalue (MAXEIG), and Latent Mode (L-mode). Sets of simulated categorical and dimensional data, along with the comparison curve fit indices (CCFI), oriented the study data's interpretation. The results with the three techniques pointed to a better fit with the dimensional format as opposed to the taxonic one, that is, depression represented better as a syndrome in which subjects are distributed along a continuum rather than as a discrete diagnostic entity.
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http://dx.doi.org/10.1590/0102-311x00028914 | DOI Listing |
Q Rev Biophys
January 2025
Faculty of Medicine, Department of Biophysics and Neuroscience, Wroclaw Medical University, Wrocław, Poland.
The GABA type A receptor (GABAR) belongs to the family of pentameric ligand-gated ion channels and plays a key role in inhibition in adult mammalian brains. Dysfunction of this macromolecule may lead to epilepsy, anxiety disorders, autism, depression, and schizophrenia. GABAR is also a target for multiple physiologically and clinically relevant modulators, such as benzodiazepines (BDZs), general anesthetics, and neurosteroids.
View Article and Find Full Text PDFGenet Sel Evol
January 2025
GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet-Tolosan, France.
Background: The magnitude of inbreeding depression depends on the recessive burden of the individual, which can be traced back to the hidden (recessive) inbreeding load among ancestors. However, these ancestors carry different alleles at potentially deleterious loci and therefore there is individual variability of this inbreeding load. Estimation of the additive genetic value for inbreeding load is possible using a decomposition of inbreeding in partial inbreeding components due to ancestors.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Computer Science and Technology, School of Computer Science, Northeast Electric Power University, Jilin, China.
Predicting Drug-Drug Interactions (DDIs) enables cost reduction and time savings in the drug discovery process, while effectively screening and optimizing drugs. The intensification of societal aging and the increase in life stress have led to a growing number of patients suffering from both heart disease and depression. These patients often need to use cardiovascular drugs and antidepressants for polypharmacy, but potential DDIs may compromise treatment effectiveness and patient safety.
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