Purpose: Pineal cysts are common incidental findings during magnetic resonance imaging (MRI) examinations. The etiology of pineal cyst development is still unclear. We aimed to determine whether there is an association between periventricular leukomalacia and pineal cyst prevalence.
Methods: Clinical and MRI data of 201 patients with periventricular leukomalacia (110 female, 91 male; mean age, 6 years; range, 2-18 years) and 687 control patients (355 female, 332 male; mean age, 6 years¸ range, 2-18 years) who did not have any evidence of periventricular leukomalacia were independently evaluated by two radiologists for presence or absence of pineal cyst.
Results: Pineal cysts were detected in 32.3% of the study group (65/201) and 8.4% of the control group (58/687) (P < 0.001). Patients with periventricular leukomalacia were more likely to have a pineal cyst. In terms of pineal cyst detection on MRI, interobserver reliability was high between the two radiologists.
Conclusion: The prevalence of pineal cysts is higher in patients with periventricular leukomalacia. We suggest that an ischemic process may have a role in the etiopathogenesis of pineal cyst development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463261 | PMC |
| http://dx.doi.org/10.5152/dir.2014.14329 | DOI Listing |
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Article Synopsis
- Pineal cysts are benign growths in the pineal gland often found accidentally during MRIs, usually causing no symptoms but can lead to neurological issues if they grow.
- The exact causes of these cysts are unclear, but factors like inflammation from conditions like fibromyalgia and mechanical stress may contribute, along with potential links to long-term lithium use in psychiatric treatment.
- A case study of a 49-year-old woman with bipolar disorder on lithium highlighted possible connections between cyst formation, systemic inflammation, and psychiatric conditions, indicating the need for more research on these interactions.
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