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Association of early maternal hypertriglyceridemia with pregnancy-induced hypertension. | LitMetric

Association of early maternal hypertriglyceridemia with pregnancy-induced hypertension.

Arch Gynecol Obstet

Department of Obstetric and Gynaecology, Pt. B. D. Sharma, PGIMS, Rohtak, Haryana, India.

Published: November 2015

Background: Hypertensive diseases are directly responsible for 24 % of maternal deaths in India. A screening method is yet to be discovered to reduce the morbidity and mortality related to it. Serum triglyceride (TG) levels are reported to increase in hypertensive pregnant women.

Aim: To predict pregnancy-induced hypertension (PIH) by serum triglyceride values.

Method: This study is a prospective cohort study that was conducted over three hundred normotensive, primigravida women with singleton pregnancy at 14-20 weeks of gestation. These were divided into two groups on the basis of their TG concentration estimated at 14-20 weeks of gestation. The pregnancy was then followed till delivery and, signs and symptoms of PIH were noted in both the groups.

Results: Out of 300 women, 210 women completed the study. Fifty-nine women developed PIH and 151 women remained normotensive. Among 59 women, 45 women had raised TG values i.e., ≥160 mg/dL and 14 women were with normal TG levels i.e., <160 mg/dL. A significant positive correlation was found between serum TG concentration and systolic and diastolic blood pressure. It was observed that a cutoff of 162.50 mg/dL for TG could reliably predict PIH with sensitivity of 76 % and specificity of 85 %. Also, the mothers with hypertriglyceridemia were found to be at higher risk of developing early-onset PIH.

Conclusion: Our study supports the evidence that early pregnancy hypertriglyceridemia is associated with an increased risk of PIH.

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Source
http://dx.doi.org/10.1007/s00404-015-3706-1DOI Listing

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