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Miller fisher syndrome with positive anti-GQ1b/GT1a antibodies associated with COVID-19 infection: A case report.
World J Clin Cases
November 2024
Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China.
Background: Miller fisher syndrome (MFS) is a variant of Guillain-Barré syndrome, an acute immune-mediated peripheral neuropathy that is often secondary to viral infections. Anti-ganglioside antibodies play crucial roles in the development of MFS. The positive rate of ganglioside antibodies is exceptionally high in MFS patients, particularly for anti-GQ1b antibodies.
View Article and Find Full Text PDFUnraveling the Spectrum of Ocular Toxicity with Oxaliplatin: Clinical Feature Analysis of Cases and Pharmacovigilance Assessment of the US Food and Drug Administration Adverse Event Reporting System Database.
Clin Ther
December 2024
Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:
Article Synopsis
- This study investigates ocular adverse events (oAEs) linked to oxaliplatin, a chemotherapy drug, through a systematic review of case reports and analysis of patient data.
- Out of 20 reported cases, a majority (84.2%) experienced loss of vision, with other symptoms including eyelid conditions and optic disc swelling; about 4.28% of oxaliplatin-related adverse event reports involved these ocular issues, with a high rate of serious outcomes.
- The analysis also identified significant safety signals for various unexpected ocular injuries, indicating a need for increased awareness of these potential adverse effects among healthcare providers and patients.
Type and Frequency of Misdiagnosis and Time Lag to Diagnosis in Patients with Chronic Progressive External Ophthalmoplegia.
J Ophthalmic Vis Res
September 2024
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Article Synopsis
- Patients with chronic progressive external ophthalmoplegia (CPEO) are frequently misdiagnosed with congenital ptosis or ocular myasthenia gravis, often leading to unnecessary surgical procedures before receiving the correct diagnosis.
- A study of 32 CPEO patients revealed an average diagnostic delay of about 25 years, with many having undergone multiple eyelid surgeries prior to CPEO confirmation.
- Emphasizing the importance of early family history review and awareness of other CPEO symptoms could help reduce the rate of misdiagnosis and improve timely intervention.
Seven Novel Variants of Weiss-Kruszka Syndrome and Phenotype Expansion.
Am J Med Genet A
February 2025
Hunter Genetics, Hunter New England Health Service, Newcastle, Australia.
Article Synopsis
- * So far, 32 cases have been documented, with significant differences in symptoms observed among patients.
- * The study analyzed nine patients and discovered seven new variants of the ZNF462 gene, finding that they share notable facial similarities, and calls for more research to understand the long-term effects of WKS.
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