Multiple pressure ulcer (PU) risk assessment instruments have been developed and tested, but there is no general consensus on which instrument to use for specific patient populations and care settings. The purpose of this study was to determine the reliability and predictive validity of the Turkish version of the Risk Assessment Pressure Sore (RAPS) instrument, which includes 12 variables--5 from the modified Norton Scale, 3 from the Braden Scale, and 3 from other research results--for use in intensive care unit (ICU) patients. The English version of the RAPS instrument was translated into Turkish and tested for internal consistency and predictive validity (sensitivity, specificity, positive predictive value, and negative predictive value) using a convenience sample of 122 patients consecutively admitted to an ICU unit in Turkey. The patients were assessed within 24 hours of admission, and after that, once a week until the development of a PU or discharge from the unit. The incidence of PUs in this population was 23%. The majority of ulcers that developed were Stage I. Internal consistency of the RAPS tool was adequate (Cronbach's α = 0.81). The best balance between sensitivity and specificity for ICU patients was reached at a cut-off point of ≤ 27 (ie, sensitivity = 74.2%, specificity = 31.8%, positive predictive value = 38.7%, and negative predictive value 91.3%). This is lower than the cut-off point reported in other studies of the RAPS scale. In this population of ICU patients, the RAPS scale was found to have acceptable reliability and poor validity. Additional studies to evaluate the predictive validity and reliability of the RAPS scale in other patient populations and care settings are needed.
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Surgery
January 2025
Department of Biomedical Sciences, Humanitas University, Milan, Italy; Department of Hepatobiliary & General Surgery, IRCCS Humanitas Research Hospital, Milan, Italy. Electronic address:
Background: Communicating vessels among hepatic veins in patients with tumors invading/compressing hepatic veins at their caval confluence facilitate new surgical solutions. Although their recognition by intraoperative ultrasound has been described, the possibility of preoperative detection still remains uncertain. We aimed to develop a model to predict their presence before surgery.
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January 2025
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
This study explores the relationship between 25-hydroxyvitamin D/calcium/alkaline phosphatase (ALP) levels and kidney stone development via cross-sectional and Mendelian randomization (MR) analyses. We used data from the National Health and Nutrition Examination Survey (NHANES) 2013 to 2018 to explore the associations of 25(OH)D metabolite, calcium, and ALP levels with kidney stone development, LDSC analysis to determine the associations between their genetically predicted levels and kidney stone development, and MR analysis to determine the causality of those relationship via genome-wide association studies (GWASs). The cross-sectional study revealed a relationship between ALP levels and kidney stone development (Model 1: OR = 1.
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January 2025
Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
Colorectal cancer (CRC) is one of the most common cancers worldwide and inflammation is believed to play an important role in CRC. In this study, we comprehensively analyzed the causal association between 91 circulating inflammatory cytokines and the risk of CRC using Mendelian randomization (MR). Based on genome-wide association study summary statistics, we examined the causal effects of 91 circulating inflammatory cytokines on CRC.
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January 2025
Department of Urology, Shiyan People's Hospital, Jinzhou Medical University Training Base, Shiyan, China.
The aim of this study was to evaluate the clinical benefits and outcomes of adjuvant radiation therapy on adrenocortical carcinoma (ACC) patients. All patients with ACC that were reported between 2010 and 2015 were identified from the Surveillance, Epidemiology, and End Results database. A forward-stepwise Cox proportional hazards regression was used to identify independent risk factors.
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January 2025
Department of Otolaryngology, Hangzhou Red Cross Hospital (Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine), Hangzhou, Zhejiang, China.
T-helper 17 (Th17) cells significantly influence the onset and advancement of malignancies. This study endeavor focused on delineating molecular classifications and developing a prognostic signature grounded in Th17 cell differentiation-related genes (TCDRGs) using machine learning algorithms in head and neck squamous cell carcinoma (HNSCC). A consensus clustering approach was applied to The Cancer Genome Atlas-HNSCC cohort based on TCDRGs, followed by an examination of differential gene expression using the limma package.
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