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Ocular Rosacea: An Updated Review.
Cornea
January 2025
Instituto de Oftalmologia Fundacion Conde de Valenciana IAP, Mexico City, Mexico.
Purpose: Ocular rosacea is a chronic inflammatory disorder affecting the ocular surface, often associated with cutaneous rosacea. This review aims to explore its pathogenesis, treatment approaches, and future directions for management.
Methods: A review of current literature on the pathophysiology, clinical features, and treatment strategies of ocular rosacea in adults and children (pediatric blepharokeratoconjunctivitis) was conducted.
Prospective study of peripartum group B streptococcus colonization in Japanese mothers and neonates.
Epidemiol Infect
January 2025
Department of Obstetrics and Gynecology, Juntendo University Urayasu Hospital, Chiba, Japan.
Article Synopsis
- Group B streptococcus (GBS) is a significant cause of infections in neonates and pregnant women, with Japan implementing guidelines for screening and antibiotic use, yet infections have not decreased significantly.
- Approximately 15% of pregnant women lack GBS screening, and issues like intermittent colonization lead to early-onset disease; current preventative measures don't address increasing cases of late-onset disease.
- This study found that using polymerase chain reaction for GBS detection was more effective than culture methods, highlighted the risk of horizontal transmission, and emphasized the need for better diagnostic tools and potential maternal vaccination for prevention.
Group B streptococcal infections in pregnancy and early life.
Clin Microbiol Rev
November 2024
Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, USA.
SUMMARYBacterial infections with Group B (GBS) are an important cause of adverse outcomes in pregnant individuals, neonates, and infants. GBS is a common commensal in the genitourinary and gastrointestinal tracts and can be detected in the vagina of approximately 20% of women globally. GBS can infect the fetus either during pregnancy or vaginal delivery resulting in preterm birth, stillbirth, or early-onset neonatal disease (EOD) in the first week of life.
View Article and Find Full Text PDFThe objective of this research was to investigate how dietary antimicrobial peptides (AMP), namely, Isalo scorpion cytotoxic peptide (IsCT), affect the gill physical barrier function and immune function of grass carp challenged with (). Five hundred forty grass carp were randomly allocated to six groups and fed to varying levels of IsCT in the diet (0, 0.6, 1.
View Article and Find Full Text PDFUnlocking Apoptotic Pathways: Overcoming Tumor Resistance in CAR-T-Cell Therapy.
Cancer Med
October 2024
Department of Hematology, Dongyang Hospital Affiliated to WenZhou Medical University, Jinhua, Zhejiang, China.
Background: Chimeric antigen receptor (CAR)-T-cell therapy has transformed cancer treatment, leading to remarkable clinical outcomes. However, resistance continues to be a major obstacle, significantly limiting its efficacy in numerous patients.
Objectives: This review critically examines the challenges associated with CAR-T-cell therapy, with a particular focus on the role of apoptotic pathways in overcoming resistance.
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