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SGLT2 Inhibitors in Cardiovascular Medicine: Panacea or Pandora's Box?
Br J Hosp Med (Lond)
November 2024
Department of Emergency, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are antidiabetic agents that effectively lower blood glucose levels in patients with Type 2 Diabetes Mellitus (T2DM). Beyond their glycemic control properties, SGLT2 inhibitors have demonstrated significant cardiovascular benefits, including reductions in major adverse cardiovascular events. However, the limitations of the pivotal trials investigating these outcomes have not been fully explored.
View Article and Find Full Text PDFMetabolic Liver Diseases Presenting as Pediatric Onset Hypoglycemia: A Hepatologist's Primer.
J Clin Exp Hepatol
October 2024
Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Article Synopsis
- Hypoglycemia can signal inborn metabolic errors, often seen in patients with liver issues, but there's no agreed-upon definition or diagnostic method.
- The text presents four pediatric cases of different ages who showed hypoglycemia as their main symptom.
- It also offers a systematic diagnostic guide for better identifying inherited metabolic liver diseases linked to hypoglycemia.
Screening for Perinatal Depression: Barriers, Guidelines, and Measurement Scales.
J Clin Med
October 2024
Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.
Screening for perinatal depression can lower its prevalence and ensure that mothers receive adequate treatment and support. Yet, few practitioners screen for it. The present article is a brief review of barriers to screening, and two screening scales are validated for perinatal women.
View Article and Find Full Text PDFWeight loss medications: A new Pandora's box?
Gastrointest Endosc
November 2024
Department of Medicine, University of Central Florida School of Medicine, Orlando Gastroenterology PA, Orlando, Florida, USA.
53BP1-the 'Pandora's box' of genome integrity.
DNA Repair (Amst)
December 2024
Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:
53BP1 has several functions in the maintenance of genome integrity. It functions as a key mediator involved in double-strand break (DSB) repair, which functions to maintain a balance in the repair pathway choices and in preserving genomic stability. While its DSB repair functions are relatively well-characterized, its role in DNA replication and replication fork protection is less understood.
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