AI Article Synopsis
- MRI-guided thermal ablations need reliable monitoring to effectively destroy diseased tissue while protecting healthy tissue.
- Interventional MR elastography (MRE) is introduced as a method to monitor these thermal therapies by detecting changes in the biomechanical properties of tissues in real-time.
- The study successfully demonstrated that interventional MRE could produce updated elastograms every 2.56 seconds during procedures, showing elasticity changes in swine liver and phantoms, indicating its potential for monitoring thermal ablations effectively.
Article Abstract
Purpose: MRI-guided thermal ablations require reliable monitoring methods to ensure complete destruction of the diseased tissue while avoiding damage to the surrounding healthy tissue. Based on the fact that thermal ablations result in substantial changes in biomechanical properties, interventional MR elastography (MRE) dedicated to the monitoring of MR-guided thermal therapies is proposed here.
Methods: Interventional MRE consists of a needle MRE driver, a fast and interactive gradient echo pulse sequence with motion encoding, and an inverse problem solver in real-time. This complete protocol was tested in vivo on swine and the ability to monitor elasticity changes in real-time was assessed in phantom.
Results: Thanks to a short repetition time, a reduction of the number of phase-offsets and the use of a sliding window, one refreshed elastogram was provided every 2.56 s for an excitation frequency of 100 Hz. In vivo elastograms of swine liver were successfully provided in real-time during one breath-hold. Changes of elasticity were successfully monitored in a phantom during its gelation with the same elastogram frame rate.
Conclusion: This study demonstrates the ability of detecting elasticity changes in real-time and providing elastograms in vivo with interventional MRE that could be used for the monitoring of thermal ablations.
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| http://dx.doi.org/10.1002/mrm.25694 | DOI Listing |
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