MicroRNAs in inflammatory bowel diseases: paradoxes and possibilities.

Inflamm Bowel Dis

*Department of Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom; and †Department of Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.

Published: May 2015

MicroRNAs (miRNAs) are single-stranded RNA molecules, which influence the translation of messenger RNA and hence protein synthesis. The altered expression of miRNAs in disease states in cancer and autoimmune diseases including inflammatory bowel disease is providing new insights into disease pathogenesis. This understanding is leading to consideration of the utility of miRNAs in diagnostics, prognostics, and therapeutics in inflammatory bowel disease. A literature search was conducted using the MEDLINE/PubMed databases using search terms inflammatory bowel disease, miRNA, treatment, and biomarkers.

Download full-text PDF

Source
http://dx.doi.org/10.1097/MIB.0000000000000288DOI Listing

Publication Analysis

Top Keywords

inflammatory bowel
16
bowel disease
12
disease
5
micrornas inflammatory
4
bowel
4
bowel diseases
4
diseases paradoxes
4
paradoxes possibilities
4
possibilities micrornas
4
micrornas mirnas
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!