There is significant decrease in mortality rate of newborns with system dysfunction after development of perinatal centers in Russia. But in children with small gestational age and severe inborn defects the mortality rate is still high. Main causes of mortality and severity are: multiorgan failure, immaturity, infections (virus and/or bacteria, fungi). Severity of patient's condition strongly correlates with inflammation markers. Other factors effecting on mortality rate and probability of complication in postoperative period, are appearance of resistant microbes in premature babies and inability to total elimination of infectious source.
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