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Seven challenges in modeling pathogen dynamics within-host and across scales. | LitMetric

Seven challenges in modeling pathogen dynamics within-host and across scales.

Epidemics

Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, USA.

Published: March 2015

AI Article Synopsis

Article Abstract

The population dynamics of infectious disease is a mature field in terms of theory and to some extent, application. However for microparasites, the theory and application of models of the dynamics within a single infected host is still an open field. Further, connecting across the scales--from cellular to host level, to population level--has potential to vastly improve our understanding of pathogen dynamics and evolution. Here, we highlight seven challenges in the following areas: transmission bottlenecks, heterogeneity within host, dynamic fitness landscapes within hosts, making use of next-generation sequencing data, capturing superinfection and when and how to model more than two scales.

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Source
http://dx.doi.org/10.1016/j.epidem.2014.09.009DOI Listing

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