Objective: To study possibilities of enteral oxygen therapy for the improvement of systemic oxygenation. We studied 34 critical patients.
Results: Insufflation of oxygen into intestines brought to delayed and prolonged increase of systemic oxygenation (PaO2 and PaO2/FiO2 growth, p<0.001, ANOVA, Holm-Sidack test) reaching its maximum in 9 hours after the insufflation procedure and lasting 32 hrs. Oxygen administration into stomach did not result to better oxygenation.
Conclusions: Taking into account low volumes of insufflated oxygen (from 2 to 6 L) and the duration of achieved systemic oxygenating effect, we may suggest that mechanism of systemic oxygenation was not based on the direct intestinal oxygen absorption, but rather due to normalization of the gastrointestinal tract functions and followed systemic metabolism change improving pulmonary gas exchange. Future investigations are needed to clarify mechanisms.
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